Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
452-02-008 / 452-02-008 ISMRM Abstract

Human Functional Imaging at 350 µm Isotropic resolution – probing Laminar Modulation in Individual Participants

Primary: Brain Function and fMRI - Task/Intervention Based fMRI
Secondary: Neuro - Gray Matter
452-02-008 · Methodology: Acquisition and Analysis · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 2
452-02-008 · Methodology: Acquisition and Analysis · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 2
Keywords: Laminar fMRI Ultrahigh-field MRI Submillimeter resolution
Accepted
Luca Vizioli 1, Lasse Knudsen1, Yulia Y Lazarova1, Steen Moeller1, Nils Nothnagel1, Lonike Faes1, Alireza Sadeghi-Tarakameh1, Kamil Ugurbil1, Essa Yacoub1
1Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America
Presenting Author: Luca Vizioli

Synopsis

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References

1. 1. Lawrence, S.J.D., Formisano, E., Muckli, L., and de Lange, F.P. (2019). Laminar fMRI: Applications for cognitive neuroscience. NeuroImage 197, 785–791. https://doi.org/10.1016/j.neuroimage.2017.07.004. [doi]
2. 2. Norris, D.G., and Polimeni, J.R. (2019). Laminar (f)MRI: A short history and future prospects. NeuroImage 197, 643–649. https://doi.org/10.1016/j.neuroimage.2019.04.082. [doi]
3. 3. Felleman, D.J., and Van Essen, D.C. (1991). Distributed Hierarchical Processing in the Primate Cerebral Cortex. Cereb. Cortex 1, 1–47. https://doi.org/10.1093/cercor/1.1.1. [doi]
4. 4. Haarsma, J., and Kok, P. (2025). How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders. In Current Topics in Behavioral Neurosciences. (Springer Berlin Heidelberg). https://doi.org/10.1007/7854_2025_595. [doi]
5. 5. McColgan, P., Joubert, J., Tabrizi, S.J., and Rees, G. (2020). The human motor cortex microcircuit: insights for neurodegenerative disease. Nat. Rev. Neurosci. 21, 401–415. https://doi.org/10.1038/s41583-020-0315-1. [doi]
6. 6. Insel, T.R., Landis, S.C., and Collins, F.S. (2013). The NIH BRAIN Initiative. Science 340, 687–688. https://doi.org/10.1126/science.1239276. [doi]
7. 7. Vizioli, L., Moeller, S., Dowdle, L., Grant, A., Sadeghi-Tarakameh, A., Eryaman, Y., Lagore R, R.L., Auerbach, E., Adriany, G., Knudsen, L., et al. (2024). Spanning spatial scales with functional imaging in the human brain; initial experiences at 10.5 Tesla. Preprint, https://doi.org/10.1101/2024.12.20.629800 https://doi.org/10.1101/2024.12.20.629800. [doi]
8. 8. Uğurbil, K. (2021). Ultrahigh field and ultrahigh resolution fMRI. Curr. Opin. Biomed. Eng. 18, 100288. https://doi.org/10.1016/j.cobme.2021.100288. [doi]
9. 9. Vizioli, L., Moeller, S., Dowdle, L., Akçakaya, M., De Martino, F., Yacoub, E., and Uğurbil, K. (2021). Lowering the thermal noise barrier in functional brain mapping with magnetic resonance imaging. Nat. Commun. 12. https://doi.org/10.1038/s41467-021-25431-8. [doi]
10. 10. Moeller, S., Pisharady, P.K., Ramanna, S., Lenglet, C., Wu, X., Dowdle, L., Yacoub, E., Uğurbil, K., and Akçakaya, M. (2021). NOise reduction with DIstribution Corrected (NORDIC) PCA in dMRI with complex-valued parameter-free locally low-rank processing. NeuroImage 226. https://doi.org/10.1016/j.neuroimage.2020.117539. [doi]
11. 11. Dowdle, L., Ghose, G., Moeller, S., Ugurbil, K., Yacoub, E., and Vizioli, L. (2022). Characterizing top-down microcircuitry of complex human behavior across different levels of the visual hierarchy. Preprint, https://doi.org/10.1101/2022.12.03.518973 https://doi.org/10.1101/2022.12.03.518973. [doi]
12. 12. Blasdel, G., and Lund, J. (1983). Termination of afferent axons in macaque striate cortex. J. Neurosci. 3, 1389–1413. https://doi.org/10.1523/JNEUROSCI.03-07-01389.1983. [doi]
13. 13. Feinberg, D.A., Beckett, A.J.S., Vu, A.T., Stockmann, J., Huber, L., Ma, S., Ahn, S., Setsompop, K., Cao, X., Park, S., et al. (2023). Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla. Nat. Methods 20, 2048–2057. https://doi.org/10.1038/s41592-023-02068-7. [doi]
14. 14. Chen, G., Wang, F., Gore, J.C., and Roe, A.W. (2013). Layer-specific BOLD activation in awake monkey V1 revealed by ultra-high spatial resolution functional magnetic resonance imaging. NeuroImage 64, 147–155. https://doi.org/10.1016/j.neuroimage.2012.08.060. [doi]
15. 15. Goense, J.B.M., and Logothetis, N.K. (2006). Laminar specificity in monkey V1 using high-resolution SE-fMRI. Magn. Reson. Imaging 24, 381–392. https://doi.org/10.1016/j.mri.2005.12.032. [doi]
16. 16. Knudsen, L., Lazarova, Y., Moeller, S., Nothnagel, N., Faes, L., Ugurbil, K., Yacoub, E., and Vizioli, L. (2025). Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI. Preprint.

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http://echo.ismrm.org/p/ISMRM2026/452-02-008