505-04-004 ISMRM Abstract

Imaging the Human Hippocampus at 10.5T fMRI: Surpassing Current Resolution Limits

Primary: Brain Function and fMRI - fMRI & Neuromodulation

Secondary: Brain Function and fMRI - fMRI Acquisition

505-04-004 · Mesoscale Functional MRI · Wednesday, 13 May, 4:00 PM–5:50 PM · Ballroom West

Keywords: Hippocampus 10.5T Subject-specific MRI Hippocampal subfields Submillimeter resolution

Accepted

Yulia Y Lazarova ¹, Lasse Knudsen¹, Steen Moeller¹, Nils Nothnagel¹, Lonike Faes¹, Essa Yacoub¹, Kamil Ugurbil¹, Luca Vizioli¹

¹Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, United States of America

Presenting Author: Yulia Y Lazarova

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Scoville, W. B., and Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiatr. 20, 11–21.

2. Small, Scott A., Scott A. Schobel, Richard B. Buxton, Menno P. Witter, and Carol A. Barnes. “A Pathophysiological Framework of Hippocampal Dysfunction in Ageing and Disease.” Nature Reviews Neuroscience 12, no. 10 (2011): 585–601. https://doi.org/10.1038/nrn3085. [doi]

3. Vizioli, L., Moeller, S., Dowdle, L., Akcakaya, M., De Martino, F., Yacoub, E. & Ugurbil, K., Lowering the thermal noise barrier in functional brain mapping with magnetic resonance imaging. (2021) Nat Commun 12, 5181, doi:10.1038/s41467-021-25431-8. [doi]

4. Canada, Kelsey L., Negar Mazloum-Farzaghi, Gustaf Rådman, et al. “A (Sub)Field Guide to Quality Control in Hippocampal Subfield Segmentation on High-Resolution T2-Weighted MRI.” Human Brain Mapping 45, no. 15 (2024): e70004. https://doi.org/10.1002/hbm.70004. [doi]

5. Berron, D., P. Vieweg, A. Hochkeppler, et al. “A Protocol for Manual Segmentation of Medial Temporal Lobe Subregions in 7 Tesla MRI.” NeuroImage: Clinical 15 (January 2017): 466–82. https://doi.org/10.1016/j.nicl.2017.05.022. [doi]

6. Ahmadi, Khazar, Stephanie Swegle, Sriranga Kashyap, et al. “Blood Volume Sensitive Laminar fMRI with VASO in Human Hippocampus: Capabilities and Biophysical Challenges at Clinical 7T Scanners.” Preprint, bioRxiv, August 29, 2025. https://doi.org/10.1101/2025.08.25.672075. [doi]

7. Hodgetts, Carl J., Natalie L. Voets, Adam G. Thomas, Stuart Clare, Andrew D. Lawrence, and Kim S. Graham. “Ultra-High-Field fMRI Reveals a Role for the Subiculum in Scene Perceptual Discrimination.” The Journal of Neuroscience 37, no. 12 (2017): 3150–59. https://doi.org/10.1523/JNEUROSCI.3225-16.2017. [doi]

8. Zhang, Kaihua, Liuyi Chen, Yinghao Li, et al. “Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.” The Journal of Neuroscience 43, no. 16 (2023): 2874–84. https://doi.org/10.1523/JNEUROSCI.1488-22.2023. [doi]

9. Suthana, Nanthia A., Markus Donix, David R. Wozny, et al. “High-Resolution 7T fMRI of Human Hippocampal Subfields during Associative Learning.” Journal of Cognitive Neuroscience 27, no. 6 (2015): 1194–206. https://doi.org/10.1162/jocn_a_00772. [doi]

10. Knierim, James J., Joshua P. Neunuebel, and Sachin S. Deshmukh. “Functional Correlates of the Lateral and Medial Entorhinal Cortex: Objects, Path Integration and Local-Global Reference Frames.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369, no. 1635 (2014): 20130369. https://doi.org/10.1098/rstb.2013.0369. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/505-04-004