465-01-004 ISMRM Abstract

UV-induced hyperpolarization for in vivo 13C-MRI in awake mice: comparison with the trityl radical method

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Neuro - Alzheimer's Disease

465-01-004 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F

Keywords: 1-13C Pyruvate Hyperpolarized 13C MRI Brain energy metabolism Amyloid precursor protein (APP) Awake mouse

Accepted

Maiko Ono ¹, Andrea Capozzi², Kosei Hirata^1,3, Chikara Yamauchi¹, Keita Saito¹, Mor Mishkovsky⁴, Yuhei Takado¹

¹Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan

²Polarize, Frederiksberg, Denmark

³Department of Neuroscience, Genetics, and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America

⁴Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Presenting Author: Maiko Ono

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References

1. Ardenkjaer-Larsen J.H., Fridlund B., Gram A., et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc. Natl. Acad. Sci. U. S. A., 2003; 100(18):10158-10163. doi: 10.1073/pnas.1733835100. [doi]

2. Eichhorn T.R., Takado Y., Salameh N., et al. Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging. Proc. Natl. Acad. Sci. U. S. A., 2013; 110(45):18064-18069. doi: 10.1073/pnas.1314928110. [doi]

3. Capozzi A., Karlsson M., Zhao Y., et al. In-vivo real-time 13C-MRSI without polarizer on site: across cities transportable hyperpolarization using UV-induced labile radicals. 2025; arXiv:2503.18537. doi: 10.48550/arXiv.2503.18537. [doi]

4. Hirata K., Matsuoka K., Tagai K., et al. Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease. Annals of Neurology, 2024; 95(1):104-115. doi: 10.1002/ana.26797. [doi]

5. Saito T., Matsuba Y., Mihira N., et al. Single App knock-in mouse models of Alzheimer’s disease. Nat. Neurosci., 2014; 17(5):661–663. doi: 10.1038/nn.3697. [doi]

6. Ono M., Kono R., Hirata K., et al. Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice. Front. Neuroimaging, 2025; 4:1506126. doi: 10.3389/fnimg.2025.1506126. [doi]

7. SpinAligner User Manual v5.

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http://echo.ismrm.org/p/ISMRM2026/465-01-004