Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-002 ISMRM Abstract

Glymphatic Dysfunction Measured by an Age-Corrected ΔALPS Index is Linked to Motor Symptoms in Early Parkinson's Disease

Primary: Neuro - Parkinson's Disease
Secondary: Diffusion - DWI/DTI/DKI
460-05-002 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Diagnosis/Prediction Glymphatics Neurodegeneration Age
Accepted
Yuan Tian 1, Xiaopeng Qu1, jianxiu lian2,3,4, Pengfei Liu5,6
1First Affiliated Hospital of Harbin Medcial University, China
2Philips Healthcare, Guangzhou, China
3Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
4Philips Healthcare (Beijing), Beijing, China
5Department of Magnetic Resonance, The First Affiliated Hospital of Harbin Medical University, Harbin, China
6The First Affiliated Hospital of Harbin Medical University, Harbin, China
Presenting Author: Yuan Tian

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. 1. Jessen NA, Munk ASF, Lundgaard I, Nedergaard M. The Glymphatic System: A Beginner's Guide. Neurochem Res. 2015;40(12):2583-99. 10.1007/s11064-015-1581-6 [doi]
2. 2. Voumvourakis KI, Sideri E, Papadimitropoulos GN, Tsantzali I, Hewlett P, Kitsos D, et al. The Dynamic Relationship between the Glymphatic System, Aging, Memory, and Sleep. Biomedicines. 2023;11(8):13. 10.3390/biomedicines11082092 [doi]
3. 3. Taoka T, Ito R, Nakamichi R, Nakane T, Kawai H, Naganawa S. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method. Magn Reson Med Sci. 2024;23(3):268-90. 10.2463/mrms.rev.2023-0175 [doi]
4. 4. Lü, X. Y. (2025). Sex and hemisphere differences in age-related trends of glymphatic system MRI markers in adults [Master’s thesis, Guizhou Medical University]. CNKI.
5. 5. Alves G, Larsen JP, Emre M, Wentzel-Larsen T, Aarsland D. Changes in motor subtype and risk for incident dementia in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2006;21(8):1123-30. 10.1002/mds.20897 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-05-002