Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
660-03-010 ISMRM Abstract

Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma using amide proton transfer-weighted MRI

Primary: Body - Liver
Secondary: Contrast Mechanisms - CEST / APT / NOE
660-03-010 · Advances in Chemical Exchange MRI: CEST, APT, and NOE I · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row A
Keywords: Magnetic Resonance Imaging (MRI) Hepatocellular carcinoma Amide proton transfer
Accepted
Zhaorong Wang 1,2, Jiale Hang2, Furong Wan2, Yingying Peng2, Jie Shi3, Jing Ye2, Xianfu Luo2
1Dalian Medical University, Dalian, China
2Northern Jiangsu People’s Hospital, Yangzhou, China
3MR Research, Beijing, China
Presenting Author: Zhaorong Wang

Synopsis

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References

1. Nagtegaal ID, Odze RD, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182-188. doi:10.1111/his.13975 [doi]
2. Ziol M, Poté N, Amaddeo G, et al. Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance. Hepatology. 2018;68(1):103-112. doi:10.1002/hep.29762 [doi]
3. Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med. 2003;9(8):1085-1090. doi:10.1038/nm907 [doi]
4. Zhou J, Zaiss M, Knutsson L, et al. Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magn Reson Med. 2022;88(2):546-574. doi:10.1002/mrm.29241 [doi]
5. Dou W, Lin CE, Ding H, et al. Chemical exchange saturation transfer magnetic resonance imaging and its main and potential applications in pre-clinical and clinical studies. Quant Imaging Med Surg. 2019;9(10):1747-1766. doi:10.21037/qims.2019.10.03 [doi]
6. Seo N, Jeong HK, Choi JY, et al. Liver MRI with amide proton transfer imaging: feasibility and accuracy for the characterization of focal liver lesions. Eur Radiol. 2021;31(1):222-231. doi:10.1007/s00330-020-07122-y [doi]
7. Wu B, Jia F, Li X, et al. Amide Proton Transfer Imaging vs Diffusion Kurtosis Imaging for Predicting Histological Grade of Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2020;7:159-168. Published 2020 Oct 9. doi:10.2147/JHC.S272535 [doi]
8. Huang J, Shen D, Sun J, et al. Amide proton transfer-weighted MRI distinguishes hepatocellular carcinoma from mass-forming intrahepatic cholangiocarcinoma. Magn Reson Imaging. 2025;123:110491. doi:10.1016/j.mri.2025.110491 [doi]
9. Mulé S, Galletto Pregliasco A, Tenenhaus A, et al. Multiphase Liver MRI for Identifying the Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma. Radiology. 2020;295(3):562-571. doi:10.1148/radiol.2020192230 [doi]

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http://echo.ismrm.org/p/ISMRM2026/660-03-010