Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
551-02-005 / 551-02-005 ISMRM Abstract

Metabolic Imaging of Hyperpolarized 13C Pyruvate in a Murine Model of Polycystic Kidney Disease

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Body - Kidney
551-02-005 · MRI of Renal Function · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
551-02-005 · MRI of Renal Function · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: Metabolic imaging Kidney diseases Hyperpolarized 13C
Accepted
Abubakr Eldirdiri1, Joshua Rogers1, Salaheldeen Elsaid1, kimia kamrani1, Patricia Outeda Garcia2, Molly J Goodfellow3, Owen Woodward4, Terry Watnick2, Sui-Seng Tee1, Dirk Mayer1
1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, United States of America
2Nephrology, Medicine, University of Maryland School of Medicine, Baltimore, United States of America
3Anesthesiology, University of Maryland School of Medicine, Baltimore, United States of America
4Physiology, University of Maryland School of Medicine, Baltimore, United States of America
Presenting Author: Jiachen Zhuo

Synopsis

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References

1. Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters DJ, Torres VE. Polycystic kidney disease. Nature reviews Disease primers. 2018;4(1):50. https://doi.org/10.1038/s41572-018-0047-y [doi]
2. Rowe I, Chiaravalli M, Mannella V, Ulisse V, Quilici G, Pema M, Song XW, Xu H, Mari S, Qian F, Pei Y. Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nature medicine. 2013;19(4):488-93. https://doi.org/10.1038/nm.3092 [doi]
3. Rowe I, Boletta A. Defective metabolism in polycystic kidney disease: potential for therapy and open questions. Nephrology Dialysis Transplantation. 2014 Aug 1;29(8):1480-6. https://doi.org/10.1093/ndt/gft521 [doi]
4. Menezes LF, Lin CC, Zhou F, Germino GG. Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease. EBioMedicine. 2016 Mar 1;5:183-92. https://doi.org/10.1016/j.ebiom.2016.01.027 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/551-02-005