Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-06-011 ISMRM Abstract

Subject-Specific Normative Modeling and Voxel-Wise Quantification of Manganese Clearance Dynamics in the Human Brain

Primary: Contrast Mechanisms - Contrast Agents
Secondary: Contrast Mechanisms - Relaxometry
569-06-011 · Magnetization Transfer and Relaxometry · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row J
Keywords: Quantitative MRI T1 Mapping Voxel-wise analysis Manganese Neurotoxicity
Accepted
Qi Wang1, Chia-tien Hsu1,2, Humberto Monsivais1,3, Coralie Knight1, Ulrike Dydak1,4
1Health Sciences, Purdue University, West Lafayette, United States of America
2Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
3Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, United States of America
4Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, United States of America
Presenting Author: Nathan Ooms

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Aschner, M., & Erikson, K. (2017). Manganese. Advances in Nutrition, 8(3), 520-521. https://doi.org/https://doi.org/10.3945/an.117.015305 [doi]
2. Monsivais, H., Yeh, C.-L., Edmondson, A., Harold, R., Snyder, S., Wells, E. M., Schmidt-Wilcke, T., Foti, D., Zauber, S. E., & Dydak, U. (2024). Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function. NeuroImage, 288, 120523.
3. Monsivais, H., & Dydak, U. (2025). Subject-Specific Mapping of Excess Manganese Accumulation in the Brain of Welders Using Magnetic Resonance Imaging Relaxometry. Toxics, 13(3), 157. https://www.mdpi.com/2305-6304/13/3/157
4. Rolls, E. T., Huang, C.-C., Lin, C.-P., Feng, J., & Joliot, M. (2020). Automated anatomical labelling atlas 3. NeuroImage, 206, 116189. https://doi.org/https://doi.org/10.1016/j.neuroimage.2019.116189 [doi]
5. Gaser, C., Dahnke, R., Thompson, P. M., Kurth, F., Luders, E., & the Alzheimer's Disease Neuroimaging Initiative. (2024). CAT: a computational anatomy toolbox for the analysis of structural MRI data. GigaScience, 13. https://doi.org/10.1093/gigascience/giae049 [doi]
6. Piredda, G. F., Caneschi, S., Hilbert, T., Bonanno, G., Joseph, A., Egger, K., Peter, J., Klöppel, S., Jehli, E., Grieder, M., Slotboom, J., Seiffge, D., Goeldlin, M., Hoepner, R., Willems, T., Vulliemoz, S., Seeck, M., Venkategowda, P. B., Corredor Jerez, R. A., . . . Radojewski, P. (2023). Submillimeter T1 atlas for subject-specific abnormality detection at 7T. Magnetic Resonance in Medicine, 89(4), 1601-1616. https://doi.org/https://doi.org/10.1002/mrm.29540 [doi]
7. Slater, D. A., Melie-Garcia, L., Preisig, M., Kherif, F., Lutti, A., & Draganski, B. (2019). Evolution of white matter tract microstructure across the life span. Human Brain Mapping, 40(7), 2252-2268. https://doi.org/https://doi.org/10.1002/hbm.24522 [doi]
8. Dorman, D. C., Struve, M. F., Marshall, M. W., Parkinson, C. U., James, R. A., & Wong, B. A. (2006). Tissue Manganese Concentrations in Young Male Rhesus Monkeys following Subchronic Manganese Sulfate Inhalation. Toxicological Sciences, 92(1), 201-210. https://doi.org/10.1093/toxsci/kfj206 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/569-06-011