Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-04-007 ISMRM Abstract

3.0T Multi-Parametric MRI Assessment of Knee Cartilage Degeneration and Its Molecular Correlates with β-Catenin and MMP-13

Primary: Preclinical Animal & in vitro MR - Biomarkers
Secondary: Musculoskeletal - Osteoarthritis
462-04-007 · Body, Cardiovascular, and Musculoskeletal Systems in Small Animals · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row C
Keywords: Biomarkers Osteoarthritis T1 Mapping T2 mapping Knee cartilage
Accepted
Muqing Luo1, Weiyin Vivian Liu2, Yinqi Liu1, Mengtian Ma1, Kun Zhang 3
1Department of Radiology, The First Hospital of Hunan University of Chinese Medicine, ChangSha, China
2Bayer Healthcare, Wuhan, China
3The First Hospital of Hunan University of Chinese Medicine, ChangSha, China
Presenting Author: Kun Zhang

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References

1. Sasho T, Katsuragi J, Yamaguchi S, et al. Associations of three-dimensional T1 rho MR mapping and three-dimensional T2 mapping with macroscopic and histologic grading as a biomarker for early articular degeneration of knee cartilage. Clin Rheumatol. 2017;36(9):2109-2119.
2. Mariani E, Pulsatelli L, Facchini A. Signaling pathways in cartilage repair. Int J Mol Sci. 2024;15(5):8667-8698.
3. Gold GE, Burstein D, Dardzinski B, et al. MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers. Osteoarthritis Cartilage. 2016;14 Suppl A:A76-86.
4. Bendele AM, Neelagiri M, Neelagiri V, et al. Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis. Eur J Med Chem. 2021;224:113666.
5. Shen HY, Zhou J, Xiao LN, et al. Effects of Miao medicine Wuteng Ointment on β-catenin protein and MMP-13, c-myc mRNA expression in cartilage tissue of knee osteoarthritis model rabbits based on Wnt/β-catenin signaling pathway. Chinese Journal of Gerontology. 2024;41(15):3271-3276.
6. Kajabi AW, Casula V, Ojanen S, et al. Multiparametric MR imaging reveals early cartilage degeneration at 2 and 8 weeks after ACL transection in a rabbit model. J Orthop Res. 2020;38(9):1974-1986.
7. Wang H, Shen S, Zhang J, et al. MRI T1ρ imaging for detection of early knee cartilage degeneration in rabbits. Chin J Med Imaging Technol. 2015;31(4):488-492.
8. Kester BS, Carpenter PM, Yu HJ, et al. T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis. World J Orthop. 2022;8(4):350-356.
9. He YW, Fan L, Zhang K, et al. Evaluation of a modified extended-position immobilization method for establishing a rabbit knee osteoarthritis model. Chin J Integr Med Imag. 2020;18(02):198-200+219.

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http://echo.ismrm.org/p/ISMRM2026/462-04-007