431-02-015 / 431-02-015 ISMRM Abstract

PREFUL MRI as a Biomarker of Single-Dose and Sustained Bronchodilator Response in COPD: Evidence from a Randomized Trial

Primary: Body - Lung

Secondary: Cardiovascular - Vascular and Vessel Wall

431-02-015 · A Clearer View Within: Advances in Body Imaging · Tuesday, 12 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Treatment Response Chronic obstructive pulmonary disease PREFUL MRI Bronchodilator Functional Free-Breathing Proton MRI

Accepted

Andreas Voskrebenzev ^1,2, Till F Kaireit^1,2, Marius Klein^1,2, Agilo L Kern^1,2, Lea Behrendt^1,2, Filip Klimeš^1,2,3, Robin A Müller^1,2, Thomas Kayser⁴, Frank Wacker^1,2, Jens Vogel-Claussen^1,2,5, Jens M Hohlfeld^1,2,4

¹Hannover Medical School, Hannover, Germany

²German Center for Lung Research (DZL), Munich, Germany

³Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

⁴Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Hannover, Germany

⁵Department of Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Presenting Author: Andreas Voskrebenzev

Synopsis

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References

1. Dimiene I, Hoppenot D, Vajauskas D, et al. Systemic Manifestations of COPD and the Impact of Dual Bronchodilation with Tiotropium/Olodaterol on Cardiac Function and Autonomic Integrity. J Clin Med. 2024;13(10):2937. doi:10.3390/jcm13102937 [doi]

2. Voskrebenzev A, Gutberlet M, Klimeš F, et al. Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med. 2018;79(4):2306-2314. doi:10.1002/mrm.26893 [doi]

3. Wernz MM, Voskrebenzev A, Müller RA, et al. Feasibility, Repeatability, and Correlation to Lung Function of Phase-Resolved Functional Lung (PREFUL) MRI-derived Pulmonary Artery Pulse Wave Velocity Measurements. J Magn Reson Imaging. 2024;60(5):2216-2228. doi:10.1002/jmri.29337 [doi]

4. Voskrebenzev A, Kaireit TF, Klimeš F, et al. PREFUL MRI Depicts Dual Bronchodilator Changes in COPD: A Retrospective Analysis of a Randomized Controlled Trial. Radiol Cardiothorac Imaging. 2022;4(2):e210147. doi:10.1148/ryct.210147 [doi]

5. Friedlander Y, Munidasa S, Thakar A, et al. Phase-Resolved Functional Lung (PREFUL) MRI to Quantify Ventilation: Feasibility and Physiological Relevance in Severe Asthma. Academic Radiology. 2024;31(8):3416-3426. doi:10.1016/j.acra.2024.01.039 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/431-02-015