Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
307-04-005 ISMRM Abstract

Regional Cardiac Energy Metabolism Differences at 7T in Healthy, Diabetic, and Heart Failure Patients

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Cardiovascular - Heart Failure
307-04-005 · Heart Failure · Monday, 11 May, 4:10 PM–6:00 PM · Meeting Room 1.40
Keywords: Diabetes Heart Failure 7T Phosphorous Magnetic Resonance Spectroscopy Cardiac magnetic resonance imaging
Accepted
Jabrane Karkouri 1, William D Watson2, Jonathan Weir Mc-Call3,4, Tracy Horn1, Marion Hill1, Dennis Klomp5, Stephen Hoole4, Chris Rodgers1
1Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom
2Department of Cardiovascular medicine, University of Cambridge, Cambridge, United Kingdom
3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
4Department of Radiology, University of Cambridge, Cambridge, United Kingdom
5University Medical Center Utrecht, Utrecht, Netherlands
Presenting Author: Jabrane Karkouri

Synopsis

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References

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3. Bottomley PA, Panjrath GS, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G, Weiss RG. Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death. Sci Transl Med 2013;5(215):215re213.
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7. Lopaschuk GD, Verma S. Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review. JACC Basic Transl Sci 2020;5(6):632-644.
8. Cowie MR, Fisher M. SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control. Nat Rev Cardiol 2020;17(12):761-772.
9. Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Ishikawa K, Watanabe S, Picatoste B, Flores E, Garcia-Ropero A, Sanz J, Hajjar RJ, Fuster V, Badimon JJ. Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics. J Am Coll Cardiol 2019;73(15):1931-1944.
10. Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K. Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 1997;96(7):2190-2196.
11. Karkouri J, Watson W, Forner R, Weir-McCall JR, Horn T, Hill M, Hoole S, Klomp D, Rodgers CT. Regionally resolved cardiac metabolism using a dipole-loop array coil for 7 T (31)P-MRSI. Magn Reson Med 2025;94(2):480-496.
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Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/307-04-005