Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
368-05-007 ISMRM Abstract

First in-vivo quantification of human brain potassium at 7T using a custom-built ³⁹K/¹H head coil

Primary: Physics & Engineering - High-Field MRI
Secondary: Physics & Engineering - RF Arrays & Systems
368-05-007 · All Things RF · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row I
Keywords: Quantitative Imaging X-nuclei Ultra high field MRI RF Coil Array Brain MRI
Accepted
Menglu Wu 1,2, Jon O Cleary1,2,3, Philippa Bridgen1,2,3,4, Inka Granlund2,3, David Carmichael1,2, Ozlem Ipek1,2
1Research Dept of Imaging, Physics & Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
2London Collaborative Ultra high field System (LoCUS), London, United Kingdom
3Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
4Research Dept of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
Presenting Author: Menglu Wu

Synopsis

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References

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2. DiFranco M, Yu C, Quiñonez M, Vergara JL. Inward rectifier potassium currents in mammalian skeletal muscle fibres. J Physiol. 2015 Mar 1;593(Pt 5):1213–38.
3. Huang X, Jan LY. Targeting potassium channels in cancer. J Cell Biol. 2014 July 21;206(2):151–62.
4. Gast LV, Baier LM, Chaudry O, Meixner CR, Müller M, Engelke K, et al. Assessing muscle-specific potassium concentrations in human lower leg using potassium magnetic resonance imaging. NMR Biomed. 2023;36(1):e4819.
5. Mangal J, Richardson S, Brackenier Y, Gardner M, Cio PD, Casella C, et al. Reducing motion artefact in high resolution 7T MRI using the Magnetic Resonance Minimal Motion (‘MR-MinMo’) head stabilisation device [Internet]. medRxiv; 2025 [cited 2025 Oct 27]. p. 2025.10.10.25337727. Available from: https://www.medrxiv.org/content/10.1101/2025.10.10.25337727v1
6. Gosselin MC, Neufeld E, Moser H, Huber E, Farcito S, Gerber L, et al. Development of a new generation of high-resolution anatomical models for medical device evaluation: the Virtual Population 3.0. Phys Med Biol. 2014 Aug;59(18):5287.
7. Vitvitsky VM, Garg SK, Keep RF, Albin RL, Banerjee R. Na+ and K+ ion imbalances in Alzheimer’s disease. Biochim Biophys Acta. 2012 Nov;1822(11):1671–81.
8. Groschup B, Calandra GM, Raitmayr C, Shrouder J, Llovera G, Zaki AG, et al. Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo. Sci Rep. 2024 June 14;14(1):13753.
9. Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ. Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury. J Cereb Blood Flow Metab. 2011 Jan 1;31(1):17–35.
10. Roberts BR, Doecke JD, Rembach A, Yévenes LF, Fowler CJ, McLean CA, et al. Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid. Acta Neuropathol Commun. 2016 Nov 14;4(1):119.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/368-05-007