Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-03-011 ISMRM Abstract

Imaging Infarct Progression, Penumbra, and Future Infarction using IVIM MRI in Stroke

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
463-03-011 · Metabolic Parameters in Stroke · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Stroke IVIM-DWI Preclinical Animal Models Ischemic penumbra
Accepted
Mira Liu1, Robert King2, Zeynep Vardar2, Josephine Kolstad2, Anna Kuhn2, Vania Anagnostakou2, Christopher Raskett2, Jonathan Winger3, Ana Krtolica4, Nils Henninger2, Matthew Gounis2, Mohammed Salman Shazeeb 2
1Icahn School of Medicine at Mount Sinai, New York, United States of America
2University of Massachusetts Chan Medical School, Worcester, United States of America
3Omniox, Inc., United States of America
4Swiss Rockets, Inc., Switzerland
Presenting Author: Mohammed Salman Shazeeb

Synopsis

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References

1. Brooks OW, King RM, Nossek E, et al. A canine model of mechanical thrombectomy in stroke. Journal of NeuroInterventional Surgery. 2019;11(12):1243-1248.
2. Shazeeb MS, King RM, Anagnostakou V, et al. Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis. Stroke. 2022;53(4):1363-1372.
3. Christensen S, Lansberg MG. CT perfusion in acute stroke: Practical guidance for implementation in clinical practice. Journal of Cerebral Blood Flow & Metabolism. 2018;39(9):1664-1668.
4. Winship IR. Cerebral collaterals and collateral therapeutics for acute ischemic stroke. Microcirculation. 2015;22(3):228-236.
5. Ribo M, Flores A, Rubiera M, et al. Extending the Time Window for Endovascular Procedures According to Collateral Pial Circulation. Stroke. 2011;42(12):3465-3469.
6. Federau C, Wintermark M, Christensen S, et al. Collateral blood flow measurement with intravoxel incoherent motion perfusion imaging in hyperacute brain stroke. Neurology. 2019;92(21).
7. Liu M, Saadat N, Roth S, et al. Quantification of Collateral Supply with Local-AIF Dynamic Susceptibility Contrast MRI Predicts Infarct Growth. AJNR American journal of neuroradiology. 2024;46(1).
8. Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988;168(2):497-505.
9. Liu M, Saadat N, Jeong Y, et al. Quantitative perfusion and water transport time model from multi b-value diffusion magnetic resonance imaging validated against neutron capture microspheres. Journal of Medical Imaging. 2023;10(06).
10. Liu MM, Saadat N, Roth SP, et al. A Method for Imaging the Ischemic Penumbra with MRI using IVIM. American Journal of Neuroradiology. 2025.
11. Zimmermann J, Reolon B, Michels L, et al. Intravoxel incoherent motion imaging in stroke infarct core and penumbra is related to long-term clinical outcome. Scientific Reports. 2024;14(1).
12. Leigh R, Knutsson L, Zhou J, van Zijl PCM. Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke. Journal of Cerebral Blood Flow & Metabolism. 2017;38(9):1500-1516.
13. Shazeeb MS, King RM, Brooks OW, et al. Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion. Translational Stroke Research. 2019;11(3):468-480.
14. Sigmund E, Rauh S, Federau C, et al. Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Guidelines. Journal of Magnetic Resonance Imaging. (In Progress).
15. Federau C, O'Brien K, Meuli R, Hagmann P, Maeder P. Measuring brain perfusion with intravoxel incoherent motion (IVIM): initial clinical experience. J Magn Reson Imaging. 2014;39(3):624-632.
16. Federau C. Intravoxel incoherent motion MRI as a means to measure in vivo perfusion: A review of the evidence. NMR in Biomedicine. 2017;30(11):e3780.
17. Federau C, Sumer S, Becce F, et al. Intravoxel incoherent motion perfusion imaging in acute stroke: initial clinical experience. Neuroradiology. 2014;56(8):629-635.
18. Zhu G, Federau C, Wintermark M, et al. Comparison of MRI IVIM and MR perfusion imaging in acute ischemic stroke due to large vessel occlusion. Int J Stroke. 2020;15(3):332-342.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-03-011