563-01-005 ISMRM Abstract

Sodium T2 relaxation-based signal separation in mild TBI: looking at potential sodium MRI biomarkers of injury

Primary: Neuro - Traumatic Brain Injury

Secondary: Analysis Methods - Data Processing

563-01-005 · Novel Neuro Applications · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row D

Keywords: Mild Traumatic Brain Injury Intracellular and extracellular sodium Sodium (23Na) MRI

Accepted

Alaleh Alivar^1,2, Ying-Chia Lin^1,2, Mary T Bruno^1,2, Georg Schramm³, Justin Quimbo^1,2, farng-yang foo⁴, Yongxian Qian ^1,2, Fernando E Boada⁵, Yvonne W Lui^1,2

¹Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America

²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America

³Nuclear Medicine, KU Leuven, Leuven, Belgium

⁴Department of Neurology, New York University Grossman School of Medicine, New York, United States of America

⁵Department of Radiology, Stanford Medicine, Stanford, United States of America

Presenting Author: Yongxian Qian

Synopsis

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References

1. Sullivan, K.A., et al., Psychological approaches for the management of persistent postconcussion symptoms after mild traumatic brain injury: a systematic review. Disabil Rehabil, 2020. 42(16): p. 2243-2251. [https://doi.org/10.1080/09638288.2018.1558292] [doi]

2. Qian, Y., et al., Single-quantum sodium MRI at 3 T for separation of mono-and bi-T2 sodium signals. Scientific Reports, 2025. 15(1): p. 27427. [https://doi.org/10.1038/s41598-025-07800-1] [doi]

3. Thompson, C., et al. Approaches to establishing validated cut-off scores on the Rivermead post-concussion symptoms questionnaire (RPQ). in Brain injury. 2016. Taylor & Francis Inc 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA.

4. Boada, F.E., et al., Fast three dimensional sodium imaging. Magnetic resonance in medicine, 1997. 37(5): p. 706-715. [https://doi.org/10.1002/mrm.1910370512] [doi]

5. Qian, Y., V.A. Stenger, and F.E. Boada, Parallel imaging with 3D TPI trajectory: SNR and acceleration benefits. Magnetic resonance imaging, 2009. 27(5): p. 656-663. [https://doi.org/10.1016/j.mri.2008.10.008] [doi]

6. Fischl, B., FreeSurfer. Neuroimage, 2012. 62(2): p. 774-81. [https://doi.org/10.1016/j.neuroimage.2012.01.021] [doi]

7. Schramm, G., et al., Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction. Magnetic Resonance in Medicine, 2023. [https://doi.org/10.1002/mrm.29936] [doi]

8. Alivar, A., et al., Mapping regional brain total sodium concentration - using anatomically- guided reconstruction of dual echo Sodium-23 MRI: moving toward improved accuracy and precision. AJNR Am J Neuroradiol, 2025. [https://doi.org/10.3174/ajnr.A8984] [doi]

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http://echo.ismrm.org/p/ISMRM2026/563-01-005