Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
601-03-005 ISMRM Abstract

Diffusion-regularized gradient scheme optimization for PRESS-localized edited MRS using weighted pathway suppression

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Acquisition & Reconstruction - Artifacts and Correction Strategies
601-03-005 · Spectroscopy and Spectroscopic Imaging · Thursday, 14 May, 4:00 PM–5:50 PM · Hall 1A
Keywords: Gradients MRS In vivo proton magnetic resonance spectroscopy Artifacts correction OUT OF VOXEL ARTIFACT
Accepted
Gizeaddis Simegn1, Zahra Shams1, Yulu Song1, Abdelrahman Gad1, Saipavitra Murali-Manohar1, Dunja Simicic 1, Christopher W Davies-Jenkins1, Vivek Yedavalli1, Aaron Gudmundson1,2, Helge Zoellner1, Georg Oeltzschner1, Richard AE Edden1,3
1Johns Hopkins University School of Medicine, Baltimore, United States of America
2The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, United States of America
3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, United States of America
Presenting Author: Dunja Simicic

Synopsis

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References

1. Kreis R. Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts. NMR Biomed. 2004 Oct;17(6):361–81.
2. Starck G, Carlsson A, Ljungberg M, Forssell-Aronsson E. k-space analysis of point-resolved spectroscopy (PRESS) with regard to spurious echoes in in vivo (1)H MRS. NMR Biomed. 2009 Feb;22(2):137–47.
3. Jerschow A, Muller N. Efficient simulation of coherence transfer pathway selection by phase cycling and pulsed field gradients in NMR. J Magn Reson San Diego Calif 1997. 1998 Sep;134(1):17–29.
4. Landheer K, Juchem C. Dephasing optimization through coherence order pathway selection (DOTCOPS) for improved crusher schemes in MR spectroscopy. Magn Reson Med. 2019;81(4):2209–22.
5. Oeltzschner, G., Saleh, M. G., Rimbault, D., Mikkelsen, M., Chan, K. L., Puts, N. A., & Edden, R. A. (2019). Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles of HERCULES. Neuroimage, 185, 181-190.
6. Shams Z, Gad A, Gudmundson AT, Murali-Manohar S, Davies-Jenkins CW, Simegn GL, Simicic D, Song Y, Yedavalli V, Zöllner HJ, Oeltzschner G, Edden RAE. Identifying out-of-voxel echoes in edited MRS with phase cycle inversion. bioRxiv [Preprint]. 2025 Jun 29:2025.06.26.661810. doi: 10.1101/2025.06.26.661810. PMID: 40693601; PMCID: PMC12262216. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/601-03-005