Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-03-007 ISMRM Abstract

Whole Brain Metabolites Changes in Adults with Obstructive Sleep Apnea

Accepted
Kamal R Singh1, Anshita Singh1, Diana E Kosoyan1, Dineth R Karunamuni1, Ravi S Aysola2, Sulaiman A Sheriff3, Andrew Maudsley3, Rajesh Kumar 1,4,5
1Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, United States of America
2Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, United States of America
3Department of Radiology, University of Miami, Miami, United States of America
4Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, United States of America
5Brain Research Institute, University of California Los Angeles, Los Angeles, United States of America
Presenting Author: Rajesh Kumar

Synopsis

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References

1. Campos-Rodriguez F, Pena-Grinan N, Reyes-Nunez N, et al. Mortality in obstructive sleep apnea-hypopnea patients treated with positive airway pressure. Chest. 2005; 128 (2): 624-633. doi: 10.1378/chest.128.2.624. [doi]
2. D'Ambrosio C, Bowman T, Mohsenin V. Quality of life in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure--a prospective study. Chest. 1999; 115 (1): 123-129. doi: 10.1378/chest.115.1.123. [doi]
3. Marshall NS, Wong KK, Liu PY, et al. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008; 31 (8): 1079-1085. PMID: 18714779 [pmid]
4. Lavie P, Lavie L. Cardiovascular morbidity and mortality in obstructive sleep apnea. Current pharmaceutical design. 2008; 14 (32): 3466-3473. doi: 10.2174/138161208786549317. [doi]
5. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002; 166 (10): 1382-1387. doi: 10.1164/rccm.200201-050OC. [doi]
6. Tummala S, Roy B, Vig R, et al. Non-Gaussian Diffusion Imaging Shows Brain Myelin and Axonal Changes in Obstructive Sleep Apnea. J Comput Assist Tomogr. 2017; 41 (2): 181-189. doi: 10.1097/RCT.0000000000000537. [doi]
7. Kumar R, Chavez AS, Macey PM, et al. Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea. Journal of neuroscience research. 2012; 90 (10): 2043-2052. doi: 10.1002/jnr.23083. [doi]
8. Maudsley AA, Goryawala MZ, Sheriff S. Effects of tissue susceptibility on brain temperature mapping. NeuroImage. 2017; 146: 1093-1101. doi: 10.1016/j.neuroimage.2016.09.062. [doi]
9. Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, et al. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006;19(4):492-503. doi: 10.1002/nbm.1025. [doi]
10. 1Maudsley AA, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K, et al. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med. 2009;61(3):548-59. doi: 10.1002/mrm.21875. [doi]
11. Sabati M, Sheriff S, Gu M, Wei J, Zhu H, Barker PB, et al. Multivendor implementation and comparison of volumetric whole-brain echo-planar MR spectroscopic imaging. Magn Reson Med. 2015;74(5):1209-20. doi: 10.1002/mrm.25510. [doi]
12. Chumbley JR, Friston KJ. False discovery rate revisited: FDR and topological inference using Gaussian random fields. Neuroimage. 2009;44(1):62-70. doi: 10.1016/j.neuroimage.2008.05.021. [doi]
13. Lavie L. Oxidative stress in obstructive sleep apnea and intermittent hypoxia--revisited--the bad ugly and good: implications to the heart and brain. Sleep Med Rev. 2015; 20: 27-45. doi: 10.1016/j.smrv.2014.07.003. [doi]
14. Lavie L. Intermittent hypoxia: the culprit of oxidative stress, vascular inflammation and dyslipidemia in obstructive sleep apnea. Expert Rev Respir Med. 2008; 2 (1): 75-84. doi: 10.1586/17476348.2.1.75. [doi]

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