Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-02-017 / 352-02-017 ISMRM Abstract

Volumetric MRI Analysis of Dexamethasone Response in Peritumoral Edema in Patients with Glioma

Primary: Neuro - Tumors
Secondary: Analysis Methods - Segmentation and Detection
352-02-017 · Segmentation: Automated, Scalable, and Clinically Oriented MRI Analysis · Monday, 11 May, 1:50 PM–3:26 PM · Power Pitch Theatre 2
352-02-017 · Segmentation: Automated, Scalable, and Clinically Oriented MRI Analysis · Monday, 11 May, 1:50 PM–3:26 PM · Power Pitch Theatre 2
Keywords: Segmentation Glioma Brain Tumor Segmentation Edema Volumetric segmentation
Accepted
Adel Azghadi1, Alexander F Wang2, Robin S Ghotra3,4, Sree Gongala3, Deepthi Yammani5, Michael D Staudt1, Tiffany R Hodges1, Tyler E Miller6, Chaitra Badve 4
1Department of Neurological Surgery, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America
2Case Western Reserve University School of Medicine, Cleveland, United States of America
3Department of Radiology, Case Western Reserve University, Cleveland, United States of America
4Department of Radiology, University Hospitals, Cleveland, United States of America
5University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America
6Department of Pathology and Cell Biology, Case Western Reserve University, Cleveland, United States of America
Presenting Author: Chaitra Badve

Synopsis

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References

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2. Quail DF, Joyce JA. The Microenvironmental Landscape of Brain Tumors. Cancer Cell. 2017;31(3):326-341. doi:10.1016/j.ccell.2017.02.009 [doi]
3. Giles AJ, Hutchinson M-N, Sonnemann HM, et al. Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy in glioblastoma. J Immunother Cancer. 2018;6(1):51. doi:10.1186/s40425-018-0371-3 [doi]
4. Miller TE, El Farran CA, Couturier CP, et al. Programs, origins and immunomodulatory functions of myeloid cells in glioma. Nature. 2025;640(8060):1072-1082. doi:10.1038/s41586-025-08633-8 [doi]
5. Alberta Provincial CNS Tumour Team. The Use of Dexamethasone in Patients with High-Grade Gliomas. Curr Oncol. 2014;21(3):e493-e503. doi:10.3747/co.21.1896 [doi]
6. Vecht CJ, Hovestadt A, Verbiest HB, van Vliet JJ, van Putten WLJ. Dose-effect relationship of dexamethasone on peritumoral brain edema: a randomized study of patients with metastatic brain tumors. J Clin Oncol. 1994;12(3):491-495. doi:10.1200/JCO.1994.12.3.491 [doi]
7. Hayward R, et al. Steroid Dosing and Cerebral Edema in Glioma: Systematic Review and Practice Variation. J Neurooncol. 2020;147(1):1-10. doi:10.1007/s11060-019-03238-4 [doi]
8. Davatzikos C, Rathore S, Bakas S, et al. Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome. J Med Imaging. 2018;5(1):011018. doi:10.1117/1.JMI.5.1.011018 [doi]
9. Pati S, Singh A, Rathore S, et al. The Cancer Imaging Phenomics Toolkit (CaPTk): technical overview. In: BrainLes 2019. Lecture Notes in Computer Science. Vol 11993. Springer; 2020:380-394. doi:10.1007/978-3-030-46643-5_38 [doi]
10. Center for Biomedical Image Computing and Analytics (CBICA). CaPTk Preprocessing – BraTS. https://cbica.github.io/CaPTk/preprocessing_brats.html
11. Rohlfing T, Zahr NM, Sullivan EV, Pfefferbaum A. The SRI24 multichannel atlas of normal adult human brain structure. Hum Brain Mapp. 2010;31(5):798-819. doi:10.1002/hbm.20906 [doi]
12. Shattuck DW, Mirza M, Adisetiyo V, et al. Construction of a 3D probabilistic atlas of human cortical structures. Neuroimage. 2007;37(4):1066-1078. doi:10.1016/j.neuroimage.2007.09.031 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-02-017