Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-016 ISMRM Abstract

Understanding metabolic differences in amyloid-beta and tau pathology by in vivo hyperpolarized mri

Primary: Neuro - Alzheimer's Disease
Secondary: Preclinical Animal & in vitro MR - Biomarkers
465-01-016 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Metabolism Alzheimer's Disease Hyperpolarized MR (Non-Gas) 1-13C Pyruvate Animal MRI
Accepted
Julia R Zickus 1, José S Enriquez1, Khloe L Kelley1, Bill T Sun1, Aldo Morales1, Jorge DeLaCerda1, Xudong Qiu1, Muxin Wang1, David Piwnica-Worms1, Seth T Gammon1, Jeffrey S Wefel2, William J Ray3, Pratip K Bhattacharya1
1Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, United States of America
2Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States of America
3Neurodegeneration Consortium, The University of Texas MD Anderson Cancer Center, Houston, United States of America
Presenting Author: Julia R Zickus

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References

1. 2025 Alzheimer's disease facts and figures. (2025). Alzheimer's & Dementia, 21(4), e70235. https://doi.org/10.1002/alz.70235 [doi]
2. Kumar, A., Sidhu, J., Lui, F., & Tsao, J. W. (2024). Alzheimer Disease. In StatPearls. StatPearls Publishing. PMID: 29763097 [pmid]
3. Wu, L., Zhang, X., & Zhao, L. (2018). Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(30), 6665–6681. https://doi.org/10.1523/JNEUROSCI.2262-17.2018 [doi]
4. An, Y., Varma, V. R., Varma, S., Casanova, R., Dammer, E., Pletnikova, O., Chia, C. W., Egan, J. M., Ferrucci, L., Troncoso, J., Levey, A. I., Lah, J., Seyfried, N. T., Legido-Quigley, C., O'Brien, R., & Thambisetty, M. (2018). Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 14(3), 318–329. https://doi.org/10.1016/j.jalz.2017.09.011 [doi]
5. Wang, Z. J., Ohliger, M. A., Larson, P. E. Z., Gordon, J. W., Bok, R. A., Slater, J., Villanueva-Meyer, J. E., Hess, C. P., Kurhanewicz, J., & Vigneron, D. B. (2019). Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology, 291(2), 273–284. https://doi.org/10.1148/radiol.2019182391 [doi]
6. Zhong, M.Z., Peng, T., Duarte, M.L. et al. Updates on mouse models of Alzheimer’s disease. Mol Neurodegeneration 19, 23 (2024). https://doi.org/10.1186/s13024-024-00712-0 [doi]

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http://echo.ismrm.org/p/ISMRM2026/465-01-016