604-02-007 ISMRM Abstract

Influence of pCASL labeling duration on blood-to-CSF water exchange measurements: better SNR and proof of direct exchange

Primary: Contrast Mechanisms - Arterial Spin Labelling

Secondary: Neuro - Neurofluids

604-02-007 · Perfusion, Flow, and Hemodynamics Across Scales · Thursday, 14 May, 1:40 PM–3:30 PM · Ballroom East

Keywords: Glymphatics Arterial spin labeling Water exchange Brain clearance Blood CSF Barrier

Accepted

Helena Durrant ¹, Nina Fultz¹, Emiel Roefs¹, Lydiane Hirschler¹, Matthias van Osch¹, Lena Vaclavu¹

¹C.J. Gorter MRI Center, Leiden University Medical Center, Netherlands

Presenting Author: Helena Durrant

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Bakker EN, Naessens DM and VanBavel E. Paravascular spaces: entry to or exit from the brain? Experimental physiology. 2019; 104: 1013–1017. PMID: 30582766. DOI: 10.1113/EP087424 [doi] [pmid]

2. Iliff JJ, Lee H, Yu M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. The Journal of clinical investigation. 2013; 123: 1299–1309. PMID: 23434588. DOI: 10.1172/JCI67677 [doi] [pmid]

3. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013; 342: 373–377. PMID: 24136970. DOI: 10.1126/science.1241224 [doi] [pmid]

4. Petitclerc L, Hirschler L, Wells JA, et al. Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans. Neuroimage. 2021; 245: 118755. PMID: 34826596. DOI: 10.1016/j.neuroimage.2021.118755 [doi] [pmid]

5. Petitclerc, L. (2023, November 14). Beyond perfusion: measuring water transport across brain barriers with arterial spin labeling MRI. Chapter 5: Simultaneous Measurement of Water Transport Across the Blood-Brain and Blood-CSF Barrier in the Human Brain with Arterial Spin Labeling MRI. Retrieved from https://hdl.handle.net/1887/3657163. Accessed October 28, 2025.

6. Gregori J, Schuff N, Kern R, et al. T2‐based arterial spin labeling measurements of blood to tissue water transfer in human brain. Journal of magnetic resonance imaging. 2013; 37: 332–342. PMID: 23019041. DOI: 10.1002/jmri.23822 [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/604-02-007