References
1. Reh, R. K., Dias, B. G., Nelson, C. A., Kaufer, D., Werker, J. F., Kolb, B., Levine, J. D., & Hensch, T. K. (2020). Critical period regulation across multiple timescales. Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23242–23251. https://doi.org/10.1073/pnas.1820836117
[doi]
2. Blahova, Z., Ikezawa, S., Falkai, P., Krystal, J. H., & Rangan, T. (2024). CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics. BJPsych Open, 10(S1), S72–S73. https://doi.org/10.1192/bjo.2024.230
[doi]
3. Fleischhacker, W. W., Podhorna, J., Gröschl, M., Hake, S., Zhao, Y., Huang, S., Keefe, R. S. E., Desch, M., Brenner, R., Walling, D. P., Mantero-Atienza, E., Nakagome, K., & Pollentier, S. (2021). Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: A double-blind, randomised, placebo- controlled phase 2 study. The Lancet Psychiatry, 8(3), 191–201. https://doi.org/10.1016/S2215-0366(20)30513-7
[doi]
4. Modinos, G., Allen, P., Grace, A. A., & McGuire, P. (2015). Translating the MAM model of psychosis to humans. Trends in Neurosciences, 38(3), 129–138. https://doi.org/10.1016/j.tins.2014.12.005
[doi]
5. Schobel, S. A., Chaudhury, N. H., Khan, U. A., Paniagua, B., Styner, M. A., Asllani, I., Inbar, B. P., Corcoran, C. M., Lieberman, J. A., Moore, H., & Small, S. A. (2013). Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver. Neuron, 78(1), 81–93. https://doi.org/10.1016/j.neuron.2013.02.011
[doi]
6. Howes, O. D., & Shatalina, E. (2022). Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance. Biological Psychiatry, 92(6), 501–513. https://doi.org/10.1016/j.biopsych.2022.06.017
[doi]
7. Dong, D., Wang, Y., Chang, X., Luo, C., & Yao, D. (2018). Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity. Schizophrenia Bulletin, 44(1), 168–181. https://doi.org/10.1093/schbul/sbx034
[doi]
8. King, S., Mothersill, D., Holleran, L., Patlola, S. R., Burke, T., McManus, R., Kenyon, M., McDonald, C., Hallahan, B., Corvin, A., Morris, D. W., Kelly, J. P., McKernan, D. P., & Donohoe, G. (2023). Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia. Translational Psychiatry, 13(1), 213. https://doi.org/10.1038/s41398-023-02512-4
[doi]
9. Howes, O. D., McCutcheon, R., Agid, O., de Bartolomeis, A., van Beveren, N. J. M., Birnbaum, M. L., Bloomfield, M. A. P., Bressan, R. A., Buchanan, R. W., Carpenter, W.T., Castle, D. J., Citrome, L., Daskalakis, Z. J., Davidson, M., Drake, R. J., Dursun, S., Ebdrup, B. H., Elkis, H., Falkai, P., … Correll, C. U. (2017). Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology. American Journal of Psychiatry, 174(3), 216–229. https://doi.org/10.1176/appi.ajp.2016.16050503
[doi]
10. Smith, R. E., Tournier, J.-D., Calamante, F., & Connelly, A. (2012). Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information. NeuroImage, 62(3), 1924–1938. https://doi.org/10.1016/j.neuroimage.2012.06.005
[doi]
11. Tournier, J.-D., Smith, R., Raffelt, D., Tabbara, R., Dhollander, T., Pietsch, M., Christiaens, D., Jeurissen, B., Yeh, C.-H., & Connelly, A. (2019). MRtrix3: A fast, flexible and open software framework for medical image processing and visuali
12. Deco, G., Ponce-Alvarez, A., Hagmann, P., Romani, G. L., Mantini, D., & Corbetta, M. (2014). How local excitation-inhibition ratio impacts the whole brain dynamics. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 34(23), 7886–7898. https://doi.org/10.1523/JNEUROSCI.5068-13.2014
[doi]
13. Balu, D. T. (2016). Chapter Twelve - The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment. In R. Schwarcz (Ed.), Advances in Pharmacology (Vol. 76, pp. 351–382). Academic Press. https://doi.org/10.1016/bs.apha.2016.01.006
[doi]
14. Coyle, J. T. (2012). NMDA Receptor and Schizophrenia: A Brief History. Schizophrenia Bulletin, 38(5), 920–926. https://doi.org/10.1093/schbul/sbs076
[doi]
15. Emamian, E. S., Karayiorgou, M., & Gogos, J. A. (2004). Decreased Phosphorylation of NMDA Receptor Type 1 at Serine 897 in Brains of Patients with Schizophrenia. Journal of Neuroscience, 24(7), 1561–1564. https://doi.org/10.1523/JNEUROSCI.4650-03.2004
[doi]
16. Ajunwa, C. C., Zhang, J., Collin, G., Keshavan, M. S., Tang, Y., Zhang, T., Li, H., Shenton, M. E., Stone, W. S., Wang, J., Niznikiewicz, M., & Whitfield-Gabrieli, S. (2024). Dissociable Default Mode Network Connectivity Patterns Underlie Distinct Symptoms in Psychosis Risk. bioRxiv: The Preprint Server for Biology, 2024.10.25.620271. https://doi.org/10.1101/2024.10.25.620271
[doi]