605-03-005 ISMRM Abstract

Glial metabolic alterations in an Alzheimer’s disease model with selective ApoE4-to-ApoE2 switching in the brain

Primary: Neuro - Alzheimer's Disease

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

605-03-005 · Next-Generation Neuroimaging for Alzheimer’s Disease: From Molecules to Networks · Thursday, 14 May, 4:00 PM–5:50 PM · Ballroom West

Keywords: Alzheimer's Disease Hyperpolarized 13C MRI Brain energy metabolism Microglia Astrocyte

Accepted

Tamara Vasilkovska ^1,2,3, Aditya Jhajharia¹, Xiao Gao^1,3, Georgios Batsios¹, Minjie Zhu¹, Lesley Golden⁴, Georgia Nolt⁴, Ken Nakamura^2,5, Pavithra Viswanath¹, Lance A Johnson^4,6, Jeremy W Gordon¹

¹Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America

²Gladstone Institutes, San Francisco, United States of America

³Physical Therapy & Rehabilitation Science, University Of California, San Francisco (UCSF), United States of America

⁴Department of Physiology, University of Kentucky, Lexington, United States of America

⁵Department of Neurology, University Of California, San Francisco (UCSF), United States of America

⁶Sanders Brown Center of Aging, University of Kentucky, Lexington, United States of America

Presenting Author: Tamara Vasilkovska

Synopsis

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References

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4. Reiman, E. M. et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci U S A 101, 284-289 (2004). https://doi.org:10.1073/pnas.2635903100

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8. Keeney, J. T., Ibrahimi, S. & Zhao, L. Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention. J Alzheimers Dis 48, 411-424 (2015). https://doi.org:10.3233/JAD-150348

9. Wu, L. & Zhao, L. ApoE2 and Alzheimer's disease: time to take a closer look. Neural Regen Res 11, 412-413 (2016). https://doi.org:10.4103/1673-5374.179044

10. Windham, I. A. & Cohen, S. The cell biology of APOE in the brain. Trends Cell Biol 34, 338-348 (2024). https://doi.org:10.1016/j.tcb.2023.09.004

11. Hasel, P., Aisenberg, W. H., Bennett, F. C. & Liddelow, S. A. Molecular and metabolic heterogeneity of astrocytes and microglia. Cell Metab 35, 555-570 (2023). https://doi.org:10.1016/j.cmet.2023.03.006

12. Qi, G. et al. ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism. Cell Rep 34, 108572 (2021). https://doi.org:10.1016/j.celrep.2020.108572

13. Williams, H. C. et al. APOE alters glucose flux through central carbon pathways in astrocytes. Neurobiol Dis 136, 104742 (2020). https://doi.org:10.1016/j.nbd.2020.104742

14. Golden, L. R. & Johnson, L. A. APOE Allele Switching in a Novel Transgenic Mouse Model as a Therapeutic Approach for Alzheimer’s Disease. Alzheimer's & Dementia 18, e060213 (2022). https://doi.org:https://doi.org/10.1002/alz.060213 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/605-03-005