Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-06-014 ISMRM Abstract

Baseline Body Composition Metrics from MR-Guided Radiotherapy Predict Post-Treatment Quality-of-Life in Prostate Cancer

Primary: Body - Body Composition
Secondary: Interventional - MR-Guided Radiotherapy
369-06-014 · Advances in Interventional MRI: Guidance, Motion Management, and Precision Treatment Technologies · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row J
Keywords: Prostate cancer Automated segmentation Quality of Life MR guided radiation therapy Body Composition Analysis
Accepted
Aaron G Rankin1,2,3,4, Dónal McSweeney1,2, Jim Zhong5, Angela Davey1,2, Marianne C Aznar1,2, Ananya Choudhury1,6, Shaista Hafeez7,8, Helena M Verkooijen9, Danny Vespirini10, Ulke A van der Heide11, Alan McWilliam1,2
1Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom
2Department of Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, United Kingdom
3Institute of Sport, Department of Sport and Exercise Science, Manchester Metropolitan University, Manchester, United Kingdom
4Manchester United Football Club, Manchester, United Kingdom
5Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
6The Christie NHS Foundation Trust, Manchester, United Kingdom
7The Institute of Cancer Research, Sutton, United Kingdom
8The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
9University Medical Center Utrecht, Utrecht, Netherlands
10Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
11the Netherlands Cancer Institute, Amsterdam, Netherlands
Presenting Author: Aaron G Rankin

Synopsis

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References

1. Anjanappa, M., Corden, M., Green, A., et al. Sarcopenia in cancer: Risking more than muscle loss. Technical Innovations & Patient Support in Radiation Oncology, 16 (2020). https://doi.org/10.1016/j.tipsro.2020.10.001. ISSN: 2405-6324. [doi]
2. Vickers, A. J., McSweeney, D. M., Choudhury, A., Weaver, J., Price, G., & McWilliam, A. The prognostic significance of sarcopenia in patients treated with definitive radiotherapy: A systematic review. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, (Dec. 6, 2024), 110663. https://doi.org/10.1016/j.radonc.2024.110663. ISSN: 1879-0887. PMID: 39647527. [doi] [pmid]
3. Siegel, D. A., O’Neil, M. E., Richards, T. B., Dowling, N. F., & Weir, H. K. Prostate cancer incidence and survival, by stage and race/ethnicity – United States, 2001–2017. MMWR. Morbidity and Mortality Weekly Report, 69(41), 1473–1480 (Oct. 16, 2020). https://doi.org/10.15585/mmwr.mm6941a1. ISSN: 1545-861X. PMID: 33056955. [doi] [pmid]
4. Chiang, P. K., Tsai, W.-K., Chiu, A. W.-H., Lin, J.-B., Yang, F.-Y., & Lee, J. Muscle loss during androgen deprivation therapy is associated with higher risk of non-cancer mortality in high-risk prostate cancer. Frontiers in Oncology, 11, 722652 (Sept. 17, 2021). https://doi.org/10.3389/fonc.2021.722652. ISSN: 2234-943X. PMID: 34604058. [doi] [pmid]
5. Chang, D., Joseph, D. J., Ebert, M. A., et al. Effect of androgen deprivation therapy on muscle attenuation in men with prostate cancer. Journal of Medical Imaging and Radiation Oncology, 58(2), 223–228 (2014). https://doi.org/10.1111/1754-9485.12124. ISSN: 1754-9485. [doi]
6. Lauretani, F., Russo, C. R., Bandinelli, S., et al. Age-associated changes in skeletal muscles and their effect on mobility: An operational diagnosis of sarcopenia. Journal of Applied Physiology, 95(5), 1851–1860 (Nov. 2003). https://doi.org/10.1152/japplphysiol.00246.2003. ISSN: 8750-7587. [doi]
7. Tolonen, A., Pakarinen, T., Sassi, A., et al. Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: A review. European Journal of Radiology, 145, 109943 (2021). https://doi.org/10.1016/j.ejrad.2021.109943. ISSN: 0720-048X. [doi]

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http://echo.ismrm.org/p/ISMRM2026/369-06-014