Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-01-015 ISMRM Abstract

Patterns of altered DTI metrics in arousal pathways and their association to sleep-wake activity in Dementia with Lewy Bodies

Accepted
Giovanni Sighinolfi 1, Elettra Capogna1, Davide Braghittoni1, Lorenzo Motta1, Lucia Guidi1, David Neil Manners1,2, Luisa Sambati3, Chiara La Morgia3,4, Annalena Venneri5, Raffaele Lodi1,4, Micaela Mitolo1,5, Caterina Tonon1,4
1Programma Neuroimmagini Funzionali e Molecolari, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
2Department for Life Quality Studies, University of Bologna, Bologna, Italy
3IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy
5Department of Medicine and Surgery, University of Parma, Parma, Italy
Presenting Author: Giovanni Sighinolfi

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Elder GJ, Lazar AS, Alfonso-Miller P, Taylor JP. Sleep disturbances in Lewy body dementia: A systematic review. Int J Geriatr Psychiatry. 2022 Oct;37(10):10.1002/gps.5814. doi: 10.1002/gps.5814 [doi]
2. Townsend LTJ, Anderson KN, Boeve BF, McKeith I, Taylor JP. Sleep disorders in Lewy body dementia: Mechanisms, clinical relevance, and unanswered questions. Alzheimers Dement. 2023 Nov;19(11):5264-5283. doi: 10.1002/alz.13350 [doi]
3. Seidel K, Mahlke J, Siswanto S, Krüger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rüb U. The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathol. 2015 Mar;25(2):121-35. doi: 10.1111/bpa.12168 [doi]
4. Manners DN, Gramegna LL, La Morgia C, Sighinolfi G, Fiscone C, Carbonelli M, Romagnoli M, Carelli V, Tonon C, Lodi R. Multishell Diffusion MR Tractography Yields Morphological and Microstructural Information of the Anterior Optic Pathway: A Proof-of-Concept Study in Patients with Leber's Hereditary Optic Neuropathy. Int J Environ Res Public Health. 2022 Jun 5;19(11):6914. doi: 10.3390/ijerph19116914. [doi]
5. Castellaro M, Moretto M, Baro V, Brigadoi S, Zanoletti E, Anglani M, Denaro L, Dell'Acqua R, Landi A, Causin F, d'Avella D, Bertoldo A. Multishell Diffusion MRI-Based Tractography of the Facial Nerve in Vestibular Schwannoma. AJNR Am J Neuroradiol. 2020 Aug;41(8):1480-1486. doi: 10.3174/ajnr.A6706 [doi]
6. Gramegna LL, Zoli M, Sighinolfi G, Carrozzi A, Vornetti G, Cantoni E, Guaraldi F, Asioli S, Tonon C, Manners DN, Mazzatenta D, Lodi R. Fully automated pipeline for the fiber tractography of the anterior optic pathway in patients with sellar and parasellar tumors and analysis of the microstructural alterations. Neuroimage Clin. 2025;47:103827. doi: 10.1016/j.nicl.2025.103827 [doi]
7. Smith RE, Tournier JD, Calamante F, Connelly A. Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information. Neuroimage. 2012 Sep;62(3):1924-38. doi: 10.1016/j.neuroimage.2012.06.005 [doi]
8. Tournier JD, Smith R, Raffelt D, Tabbara R, Dhollander T, Pietsch M, Christiaens D, Jeurissen B, Yeh CH, Connelly A. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019 Nov 15;202:116137. doi: 10.1016/j.neuroimage.2019.116137 [doi]
9. Dhollander T, Mito R, Raffelt D, Connelly A. Improved white matter response function estimation for 3-tissue constrained spherical deconvolution. Proceedings of the 27th annual meeting of the International Society of Magnetic Resonance in Medicine. 2019, 555
10. Jeurissen B, Tournier JD, Dhollander T, Connelly A, Sijbers J. Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data. Neuroimage. 2014 Dec;103:411-426. doi: 10.1016/j.neuroimage.2014.07.061 [doi]
11. Smith RE, Tournier JD, Calamante F, Connelly A. SIFT2: Enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography. Neuroimage. 2015 Oct 1;119:338-51. doi: 10.1016/j.neuroimage.2015.06.092 [doi]
12. Edlow B; Kinney H. Harvard Ascending Arousal Network Atlas – Version 2.0 [Dataset]. Dryad. 2023. doi: 10.5061/dryad.zw3r228d2 [doi]
13. Fan L, Li H, Zhuo J, Zhang Y, Wang J, Chen L, Yang Z, Chu C, Xie S, Laird AR, Fox PT, Eickhoff SB, Yu C, Jiang T. The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture. Cereb Cortex. 2016 Aug;26(8):3508-26. doi: 10.1093/cercor/bhw157 [doi]
14. Laurell AAS, Mak E, O'Brien JT. A systematic review of diffusion tensor imaging and tractography in dementia with Lewy bodies and Parkinson's disease dementia. Neurosci Biobehav Rev. 2025 Feb;169:106007. doi: 10.1016/j.neubiorev.2025.106007 [doi]
15. Delli Pizzi S, Franciotti R, Taylor JP, Thomas A, Tartaro A, Onofrj M, Bonanni L. Thalamic Involvement in Fluctuating Cognition in Dementia with Lewy Bodies: Magnetic Resonance Evidences. Cereb Cortex. 2015 Oct;25(10):3682-9. doi: 10.1093/cercor/bhu220 [doi]
16. Anderson J, Chiu NKH, Pye JE, Comas-Soberats M, Lam A, Grunstein RR, Lewis SJG, Matar E. Rest-Activity Disturbances Correlate with Core Features in Dementia with Lewy Bodies. Mov Disord Clin Pract. 2025 Aug;12(8):1140-1145. doi: 10.1002/mdc3.70052 [doi]

Cite this abstract