367-02-002 ISMRM Abstract

Metal-free MRI probes based on peptide self-assembly for pancreatic cancer diagnosis

Primary: Preclinical Animal & in vitro MR - Probes & Targets

Secondary: Preclinical Animal & in vitro MR - Small Animals

367-02-002 · Cancer Detection and Therapies · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row H

Keywords: Pancreatic ductal adenocarcinoma Peptide self-assembly Metal-free contrast agent

Accepted

Xin Zhao ^1,2, Hongyu Guo¹, Wentao Liu², Qian Zeng², Lei Wang², Yunan Zhao¹, Yaobang Shen², Chen Yang^1,2

¹School of Electrical Engineering, Shenyang University of Technology, Shen Yang, China

²National Center for Nanoscience and Technology, Beijing, China

Presenting Author: Xin Zhao

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References

1. Ren H, Zeng XZ, Zhao XX, Hou DY, Yao H, Yaseen M, Zhao L, Xu WH, Wang H, Li LL. A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging. Nat Commun. 2022 Jan 20;13(1):418.

2. Xu AP, Yang PP, Yang C, Gao YJ, Zhao XX, Luo Q, Li XD, Li LZ, Wang L, Wang H. Bio-inspired metal ions regulate the structure evolution of self-assembled peptide-based nanoparticles. Nanoscale. 2016 Aug 7;8(29):14078-83.

3. Wu Z, Zeng W, Yang W, Yi J, Liu D, Xu Y, Liu C, Bian K, Wang H, Zhang B. FAP-catalyzed in situ self-assembly of magnetic resonance imaging probe for early and precise staging of liver fibrosis. Sci Adv. 2025 Mar 14;11(11):eadt6082.

4. Xue X, Bo R, Qu H, Jia B, Xiao W, Yuan Y, Vapniarsky N, Lindstrom A, Wu H, Zhang D, Li L, Ricci M, Ma Z, Zhu Z, Lin TY, Louie AY, Li Y. A nephrotoxicity-free, iron-based contrast agent for magnetic resonance imaging of tumors. Biomaterials. 2020 Oct;257:120234.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-02-002