Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-05-002 ISMRM Abstract

Localizing DTI and NODDI Associations with Brain Amyloid and Tau Pathology Along White Matter Tracts

Primary: Neuro - Alzheimer's Disease
Secondary: Diffusion - Tractography
465-05-002 · Tractography Applications · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row F
Keywords: Alzheimer's Disease Tractography Diffusion MRI Diffusion Tensor Imaging Neurite orientation dispersion and density imaging
Accepted
Kenny Liou1, Yixue Feng1, Bramsh Chandio2, Sophia Thomopoulos1, Julio E Villalon Reina 1, Iyad Ba Gari1, Jonathan D Alibrando1, Hannah Yoo1, Yuhan Shuai1, Sasha Chehrzadeh1, Clifford R Jack Jr.3, Michael W Weiner4, Talia M Nir1, Neda Jahanshad1, Paul M Thompson1
1Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine., University of Southern California, Marina del Rey, CA, USA, United States of America
2Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, United States of America
3Department of Radiology, Mayo Clinic Rochester, Rochester, United States of America
4Department of Radiology and Biomedical Imaging, University of California – San Francisco, San Francisco, United States of America
Presenting Author: Julio E Villalon Reina

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Y. Feng et al., "Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure-informed normative tractometry," Alzheimer’s Dement., vol. 21, no. 1, p. e14371, Jan. 2025. doi: 10.1002/alz.14371 [doi]
2. B. Q. Chandio et al., "Amyloid, Tau, and APOE in Alzheimer's Disease: Impact on White Matter Tracts," Pacific Symposium on Biocomputing, 30:394-411, 2024.
3. P. J. Basser et al., “MR diffusion tensor spectroscopy and imaging,” Biophys. J., vol. 66, no. 1, pp. 259-267, Jan. 1994. doi: 10.1016/S0006-3495(94)80775-1 [doi]
4. K. Oishi et al., “DTI Analyses and Clinical Applications in Alzheimer’s Disease,” J. Alzheimer’s Dis., vol. 26, no. Suppl 3, pp. 287-296, 2011. doi: 10.3233/JAD-2011-0007 [doi]
5. H. Zhang et al., “NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain,” NeuroImage, vol. 61, no. 4, pp. 1000–1016, Jul. 2012. doi:10.1016/j.neuroimage.2012.03.072 [doi]
6. S. M. Landau et al., “Positron emission tomography harmonization in the Alzheimer’s Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification,” Alzheimer’s Dement., vol. 21, no. 1, p. e14378, 2025. doi:10.1002/alz.14378 [doi]
7. K. Liou et al., “DTI versus NODDI White Matter Microstructural Biomarkers of Alzheimer’s Disease,” in Proc. SIPAIM, 2025, in press.
8. B. Q. Chandio et al., "Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations," Sci. Rep., vol. 10, p. 17149, 2020. doi:10.1038/s41598-020-74054-4 [doi]
9. Yeh, F.C., Panesar, S., Fernandes, D., Meola, A., Yoshino, M., Fernandez-Miranda, J.C., Vettel, J.M. and Verstynen, T., 2018. Population-averaged atlas of the macroscale human structural connectome and its network topology. NeuroImage, 178, pp. 57-68. doi:10.1016/j.neuroimage.2018.05.027 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-05-002