469-04-011 ISMRM Abstract

CEST-MRI (3.0T, 9.4T) Evaluation of the Role of Creatine Metabolism in Skeletal Muscle Dysfunction in Knee Osteoarthritis.

Primary: Musculoskeletal - Muscle

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

469-04-011 · MRI and MRS in Muscle in Health and Disease · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row J

Accepted

Yiou Wang ¹, Tianzhao Zhong², Tao Quan³, Qinglin Xie¹, youbin Ding¹, Peng Wu⁴, Zhongping Zhang⁴, Yanqiu Feng³, Yin Wu², Xiaodong Zhang¹

¹The Third Affiliated Hospital Southern Medical University, Guangzhou, China

²Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

³School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China

⁴Philips Healthcare, Guangzhou, China

Presenting Author: Yiou Wang

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References

1. Wang, D., Marom, N., Coxe, F. R., Kalia, V., Burge, A. J., Jones, K. J., Rodeo, S. A., & Williams, R. J., 3rd (2021). Preoperative Grades of Osteoarthritis and Meniscus Volume Correlate with Clinical Outcomes of Osteochondral Graft Treatment for Cartilage Defects in the Knee. Cartilage, 12(3), 344–353. https://doi.org/10.1177/1947603519852402 [doi]

2. DeBrosse, C., Nanga, R. P. R., Wilson, N., D'Aquilla, K., Elliott, M., Hariharan, H., Yan, F., Wade, K., Nguyen, S., Worsley, D., Parris-Skeete, C., McCormick, E., Xiao, R., Cunningham, Z. Z., Fishbein, L., Nathanson, K. L., Lynch, D. R., Stallings, V. A., Yudkoff, M., Falk, M. J., … McCormack, S. E. (2016). Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders. JCI insight, 1(18), e88207. https://doi.org/10.1172/jci.insight.88207 [doi]

3. Forbes, S. C., Candow, D. G., Neto, J. H. F., Kennedy, M. D., Forbes, J. L., Machado, M., Bustillo, E., Gomez-Lopez, J., Zapata, A., & Antonio, J. (2023). Creatine supplementation and endurance performance: surges and sprints to win the race. Journal of the International Society of Sports Nutrition, 20(1), 2204071. https://doi.org/10.1080/15502783.2023.2204071 [doi]

4. Ju, L., Schär, M., Wang, K., Li, A., Wu, Y., Samuel, T. J., Ganji, S., van Zijl, P. C. M., Yadav, N. N., Weiss, R. G., & Xu, J. (2025). Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T. Magnetic resonance in medicine, 93(3), 1273–1284. https://doi.org/10.1002/mrm.30354 [doi]

5. Burman, R., Pang, Y., Bag, A., Finkel, R. S., Ness, K. K., & Bagga, P. (2025). A Novel CEST-Based Approach for Reliably Assessing Skeletal Muscle Oxidative Phosphorylation: OXCEST. Magnetic resonance in medicine, 10.1002/mrm.70133. Advance online publication. https://doi.org/10.1002/mrm.70133 [doi]

6. Wang, Y., Yan, C., Feng, X., Gao, N., Gao, J. H., & Song, X. (2025). Simultaneous quantification of PCr, Cr, and pH in muscle CEST-MRI. Magnetic resonance in medicine, 94(2), 640–650. https://doi.org/10.1002/mrm.30508 [doi]

7. Klepochová, R., Niess, F., Metz, M., Ukropcová, B., Ukropec, J., Trattnig, S., Kautzky-Willer, A., Krššák, M., & Meyerspeer, M. (2025). H and P MRS Interleaved With High Time Resolution Reveals Closely Matching Creatine CH₂ and PCr Dynamics During Exercise. NMR in biomedicine, 38(10), e70132. https://doi.org/10.1002/nbm.70132131 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/469-04-011