Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-01-001 ISMRM Abstract

Association of Oxygen Extraction Fraction in Grey Matter Nuclei with Cognitive Impairment in Cerebral Small Vessel Disease

Primary: Neuro - Blood Vessels
Secondary: Neuro - Other Neurodegeneration
366-01-001 · Cerebral Small Vessel Disease: Imaging Biomarkers, Pathophysiology, and Clinical Impact · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row G
Keywords: Oxygen extraction fraction Cognitive impairment Cerebral small vessel disease Grey Matter Nuclei
Accepted
Boyao Chen 1, Meng Li2, Yi Wang3, Qihao Zhang3, Zhenyu Cheng4, Yiwen Chen1, Pengcheng Liang1, Xinxin Huo1, Fushuai Zhang4, Jiaxiang xin5,6,7,8, Changhu Liang1, Lingfei Guo1
1Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
2Jena University Hospital, Jena, Germany
3Department of Radiology, Weill Cornell Medicine, New York, United States of America
4Binzhou Medical University, Yantai City, Shandong Province, China
5MR Collaborations, Siemens Healthineers Ltd., Shanghai, China
6Magnetic Resonance Research Collaboration, Siemens Healthineers Ltd, Shanghai, China
7Magnetic Resonance Research Collaboration, Shanghai, China
8MR Research Collaboration Team, Shanghai, China
Presenting Author: Boyao Chen

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References

1. Inoue, Y., et al., Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease. Mol Neurodegener, 2023. 18(1): p. 46. doi: 10.1186/s13024-023-00640-5 [doi]
2. Wu, L.Y., et al., Blood-based biomarkers of cerebral small vessel disease. Ageing Res Rev, 2024. 95: p. 102247. doi: 10.1016/j.arr.2024.102247 [doi]
3. Mohammadi, M., et al., Reduced Oxygen Extraction Fraction as a Biomarker for Cognitive Deficits in Obstructive Sleep Apnea. Brain Behav, 2025. 15(2): p. e70273. doi: 10.1002/brb3.70273 [doi]
4. Zhang, R., et al., Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression. Brain, 2025. 148(6): p. 1950-1962. doi: 10.1093/brain/awae383 [doi]
5. Wong, F.C.C., et al., Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment. Transl Stroke Res, 2021. 12(2): p. 284-292. doi: 10.1007/s12975-020-00847-4 [doi]

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http://echo.ismrm.org/p/ISMRM2026/366-01-001