Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-02-009 ISMRM Abstract

Glymphatic dysfunction and white-matter disruption: MRI study of chain mediation linking hydrocephalus to cognitive decline

Primary: Neuro - Hydrocephalus
Secondary: Diffusion - DWI/DTI/DKI
362-02-009 · Clinical Diffusion Neuro · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row C
Keywords: White Matter Cognitive impairments Idiopathic normal pressure hydrocephalus Mediation analysis Glymphatic Function
Accepted
Yawen Xiao 1, Jiankun Dai2, Qingqing Wen2, Xinlan Xiao1
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, China
2MR Research, Beijing, China
Presenting Author: Yawen Xiao

Synopsis

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References

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2. Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017;140(10):2691-2705. doi:10.1093/brain/awx191 [doi]
3. Eide PK, Ringstad G. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab. 2019;39(7):1355-1368. doi:10.1177/0271678x18760974 [doi]
4. Kanno S, Ogawa K ichi, Kikuchi H, et al. Reduced default mode network connectivity relative to white matter integrity is associated with poor cognitive outcomes in patients with idiopathic normal pressure hydrocephalus. BMC Neurol. 2021;21(1). doi:10.1186/s12883-021-02389-0 [doi]
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7. Zhang W, Zhou Y, Wang J, et al. Glymphatic clearance function in patients with cerebral small vessel disease. NeuroImage. 2021;238:118257. doi:10.1016/j.neuroimage.2021.118257 [doi]
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9. Sun X, Zhao C, Chen S, et al. Free Water MR Imaging of White Matter Microstructural Changes is a Sensitive Marker of Amyloid Positivity in Alzheimer’s Disease. J Magn Reson Imaging. 2024;60(4):1458-1469. doi:10.1002/jmri.29189 [doi]
10. Tai AS, Lin SH, Chu YC, Yu T, Puhan MA, VanderWeele T. Causal Mediation Analysis with Multiple Time-varying Mediators. Epidemiology. 2023;34(1):8-19. doi:10.1097/EDE.0000000000001555 [doi]
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Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-02-009