Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
603-01-002 ISMRM Abstract

Data-Driven Mapping of Cortical Thinning Patterns in Genetic and Sporadic Frontotemporal Dementia Using Longitudinal MRI

Primary: Neuro - Dementia
Secondary: Analysis Methods - Classification and Prediction
603-01-002 · Dementia Not Related to Alzheimer's Disease · Thursday, 14 May, 8:30 AM–10:20 AM · Auditorium 1
Keywords: Diagnosis/Prediction Frontotemporal dementia Disease subtyping MRI biomarkers Longitudinal MRI
Accepted
Taylor J Solomon , Terence J O'Brien1,2, Ben Sinclair3, Lucy Vivash1
1Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia
2The Alfred, Australia
3Monash University, Melbourne, Australia
Presenting Author: Taylor J Solomon

Synopsis

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References

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2. Young AL, Bocchetta M, Russell LL, Convery RS, Peakman G, Todd E, et al. Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling. Neurology. 2021;97(9):e941-e52. doi: 10.1212/WNL.0000000000012410. PMID: 34158384 [doi] [pmid]
3. Whitwell JL, Weigand SD, Boeve BF, Senjem ML, Gunter JL, DeJesus-Hernandez M, et al. Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain. 2012;135(Pt 3):794-806. doi: 10.1093/brain/aws001. PMID: 22366795 [doi] [pmid]
4. Soppela H, Katisko K, Gadola Y, Krüger J, Hartikainen P, Alberici A, et al. Modifiable potential risk factors in familial and sporadic frontotemporal dementia. Annals of Clinical and Translational Neurology. 2022;9(8):1195-205. doi: 10.1002/acn3.51619. PMID: 35767471 [doi] [pmid]
5. Benussi A, Libri I, Premi E, Alberici A, Cantoni V, Gadola Y, et al. Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study. Alzheimers Dement (N Y). 2022;8(1):e12326. doi: 10.1002/trc2.12326. PMID: 35898667 [doi] [pmid]
6. Heuer HW, Forsberg LK, Mester CT, Johnson N, Ramos EM, Kantarci K, et al. ALLFTD: Identifying and Characterizing Frontotemporal Lobar Degeneration Participants in a Multi-center North American Study. Alzheimer's & Dementia. 2023;19(S18):e080463. doi: 10.1002/alz.080463. [doi]
7. Wang L, Cen S, Zhao L, Tang J, Xu P, Quan P, et al. Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy. The Journal of Prevention of Alzheimer's Disease. 2025:100306. doi: 10.1016/j.tjpad.2025.100306. PMID: 40701902 [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/603-01-002