Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-04-004 ISMRM Abstract

Neurochemistry of SOD1 ALS neurocortical organoids using high-resolution magic angle spinning NMR spectroscopy

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Neuro - Other Neurodegeneration
665-04-004 · MR in Organoid/Phantom/Plant/Serum · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row F
Keywords: Metabolism Other Neurodegeneration Cerebral organoids HR-MAS NMR spectroscopy Amyotrophic lateral sclerosis
Accepted
Alejandra Castilla Bolaños 1,2, Colleen Bailey2, Vincent Moxley-Paquette2, Navroop Dhaliwal3, Elena Osipyan2, Fermisk Saleh4, Andre Simpson5, Carol Schuurmans3,4, Jamie Near1,2
1Department of Medical Biophysics, University of Toronto, Toronto, Canada
2Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
3Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
4Department of Biochemistry, University of Toronto, Toronto, Canada
5Department of Physical and Environmental Sciences, University of Toronto, Toronto, Canada
Presenting Author: Alejandra Castilla Bolaños

Synopsis

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References

1. Pereira JD, DuBreuil DM, Devlin AC, Held A, Sapir Y, Berezovski E, Hawrot J, Dorfman K, Chander V, Wainger BJ. Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions. Nature communications. 2021 Aug 6;12(1):4744. PMID: 34362895 [pmid]
2. Hong Y, Dong X, Chang L, Xie C, Chang M, Aguilar JS, Lin J, Lin J, Li QQ. Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases. Iscience. 2023 Mar 17;26(3). PMID: 36936782 [pmid]
3. Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'rourke NA, Nguyen KD, Smith SJ. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nature methods. 2015 Jul;12(7):671-8. PMID: 26005811. [pmid]
4. Biswas, R. G., Fortier-McGill, B., Akhter, M., Soong, R., Ning, P., Bastawrous, M., ... & Simpson, A. J. (2020). Ex vivo comprehensive multiphase NMR of whole organisms: a complementary tool to in vivo NMR. Analytica Chimica Acta: X, 6, 100051. https://doi.org/10.1016/j.acax.2020.100051 [doi]
5. Simpson R, Devenyi GA, Jezzard P, Hennessy TJ, Near J. Advanced processing and simulation of MRS data using the FID appliance (FID‐A)—an open source, MATLAB‐based toolkit. Magnetic resonance in medicine. 2017 Jan;77(1):23-33. PMID: 26715192 [pmid]
6. Castilla Bolanos MA, Chinchalongporn V, Biswas RG, Bailey C, Wu M, Soong R, Saleh F, Simpson A, Schuurmans C, Near J. Metabolic analysis in intact human-derived cerebral organoids by high-resolution magic-angle spinning NMR spectroscopy. bioRxiv. 2024 Jun 23:2024-06. https://doi.org/10.1101/2024.06.21.599412 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-04-004