Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
365-05-006 ISMRM Abstract

Correlated diffusion–relaxometry of neurofluids with echo‑shifted mGRE (ES‑QUTE): insights into CSF complexity and glymphatic

Primary: Neuro - Neurofluids
Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
365-05-006 · Novel Acquisition Methods · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row F
Keywords: Relaxometry Cerebrospinal fluid (CSF) NNLS ES-QUTE Diffusivity
Accepted
Ana-Maria Oros-Peusquens 1, Seonyeong Shin1,2, N. Jon Shah1,2,3,4,5
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany
2RWTH Aachen University, Aachen, Germany
3Department of Neurology, RWTH Aachen University, Aachen, Germany
4Aachen, JARA - BRAIN - Translational Medicine, Aachen, Germany
5Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Germany
Presenting Author: Ana-Maria Oros-Peusquens

Synopsis

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References

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3. Vikner T, et al. CSF dynamics throughout the ventricular system using 4D flow MRI. Fluids Barriers CNS. 2024;21:48. doi:10.1186/s12987-024-00570-4. [doi]
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9. Shin S, Oros‑Peusquens A‑M, Yun SD, Farrher E, Shah NJ. Development of an echo‑shifted, multi‑echo, gradient‑echo sequence for T2* quantification of slow‑relaxing water pools. Magn Reson Med. 2025; doi:10.1002/mrm.30624. [doi]
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11. Pipe JG, et al. Flow‑compensated diffusion encoding in MRI (velocity‑moment nulling). Magn Reson Med. 1999;42:963–969.
12. Finsterbusch J. Principles of flow‑compensated diffusion encoding. J Magn Reson. 2009;200:100–108.
13. Porter DA, Heidemann RM. High resolution DWI using readout‑segmented EPI with 2D navigator. Magn Reson Med. 2009;62(2):468–475.
14. Rostgaard N, et al. Differential proteomic profile of lumbar and ventricular cerebrospinal fluid. Fluids Barriers CNS. 2023;20:6. doi:10.1186/s12987-022-00405-0. [doi]
15. Reiber H. Non‑linear ventriculo–lumbar protein gradients validate the diffusion‑flow model for the blood–CSF barrier. Clin Chim Acta. 2021;513:64–67.
16. Courtney, Y., Lehtinen, M.K. Apocrine secretion by the choroid plexus. Fluids Barriers CNS 22, 75 (2025).
17. Shin S, Oros-Peusquens A, Yun S, Farrher E, Shah NJ. Development of a novel sequence for T2* quantification of slow-relaxing water pools in the brain. In: Proceedings of the 31st Annual Meeting of ISMRM, Toronto, Canada. 2023;0666

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http://echo.ismrm.org/p/ISMRM2026/365-05-006