Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-05-004 ISMRM Abstract

Generating cervical cancer probability maps with restriction spectrum imaging and machine learning

Accepted
Cassandra M Stoffer1, Lance C Moore2, Sheida Ebrahimi3, Cora Chun3, Jacqueline Loh3, Allison Bang1, Tyler M Seibert2, Elise Roeca4, Jyoti S Mayadev2, Michael McHale4, Jingjing Zou5, Ana E Rodríguez-Soto1,3, Rebecca Rakow-Penner1,3
1Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States of America, United States of America
2University of California, Berkeley, United States of America
3University of California, San Diego, La Jolla, CA, United States of America, United States of America
4Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, United States of America
5Herbert Wertheim School of Public Health & Human Longevity Science, University of California, San Diego, La Jolla, United States of America
Presenting Author: Mark Buckup

Synopsis

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References

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3): 229-263. doi:10.3322/caac.21834 [doi]
2. Lee SI, Atri M. 2018 FIGO Staging System for Uterine Cervical Cancer: Enter Cross-sectional Imaging. Radiology. 2019 Jul;292(1):15-24. doi: 10.1148/radiol.2019190088. Epub 2019 May 28. PMID: 31135294. [doi] [pmid]
3. Brunsing RL, Schenker-Ahmed NM, White NS, Parsons JK, Kane C, Kuperman J, Bartsch H, Kader AK, Rakow-Penner R, Seibert TM, Margolis D, Raman SS, McDonald CR, Farid N, Kesari S, Hansel D, Shabaik A, Dale AM, Karow DS. Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI. J Magn Reson Imaging. 2017 Feb;45(2):323-336. doi: 10.1002/jmri.25419. Epub 2016 Aug 16. PMID: 27527500; PMCID: PMC5222783. [doi] [pmid]
4. Rodríguez-Soto AE, Andreassen MMS, Fang LK, Conlin CC, Park HH, Ahn GS, Bartsch H, Kuperman J, Vidić I, Ojeda-Fournier H, Wallace AM, Hahn M, Seibert TM, Jerome NP, Østlie A, Bathen TF, Goa PE, Rakow-Penner R, Dale AM. Characterization of the diffusion signal of breast tissues using multi-exponential models. Magn Reson Med. 2022 Apr;87(4):1938-1951. doi: 10.1002/mrm.29090. Epub 2021 Dec 14. PMID: 34904726; PMCID: PMC9148547. [doi] [pmid]
5. Rodríguez-Soto AE, Conlin CC, Ebrahimi S, Besser A, Jordan S, Lundstrom E, Schlein A, Kuperman J, Dale AM, Seibert TM, McHale M, Rakow-Penner R. Restriction Spectrum Imaging (RSI) Models for Cervical Cancer. Abstract #1460, 2024 Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM). 2024. Retrieved from https://archive.ismrm.org/2024/1460.html
6. Rodríguez-Soto AE, Meriwether CH, Park AJ, Jr DWA, Wallace A, Ojeda-Fournier H, Dale AM, Rakow-Penner R. Noncontrast MRI with advanced diffusion weighted imaging for breast cancer detection in a lactating woman. Radiol Case Rep. 2020 Sep 17;15(11):2358-2361. doi: 10.1016/j.radcr.2020.08.058. PMID: 32994841; PMCID: PMC7502779. [doi] [pmid]
7. Krishnan AP, Karunamuni R, Leyden KM, Seibert TM, Delfanti RL, Kuperman JM, Bartsch H, Elbe P, Srikant A, Dale AM, Kesari S, Piccioni DE, Hattangadi-Gluth JA, Farid N, McDonald CR, White NS. Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma. AJNR Am J Neuroradiol. 2017 May;38(5):882-889. doi: 10.3174/ajnr.A5099. Epub 2017 Mar 9. PMID: 28279985; PMCID: PMC5507368. [doi] [pmid]
8. Falcon W, The PyTorch Lightning team. (2025). PyTorch Lightning (2.5.5). Zenodo. https://doi.org/10.5281/zenodo.17064382 [doi]

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