Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
630-01-010 ISMRM Abstract

Quantitative susceptibility mapping and decomposition of paramagnetic and diamagnetic components in motor neuron diseases.

Primary: Neuro - Other Neurodegeneration
Secondary: Contrast Mechanisms - Susceptibility/QSM
630-01-010 · Quantitative Susceptibility Mapping: From Phase to Tissue Properties · Thursday, 14 May, 8:30 AM–10:20 AM · Meeting Room 2.60
Keywords: MRI Amyotrophic lateral sclerosis Quantitative Susceptibility Mapping (QSM) Neuroimaging Biomarkers Chi separation
Accepted
Lorenzo Gualco 1,2, Davide Sabbadin3,4, Oliver C Kiersnowski4, Matteo Pardini1,4, Angelo Schenone1,4, Chiara Gemelli4, Pilar M Ferraro4, Alessio Signori5, Corrado Cabona4, Mirco Cosottini6,7, Graziella Donatelli6,8, Chunlei Liu9,10, Mauro Costagli1,4, Luca Roccatagliata4,5
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy
2Radiology, Santi Antonio and Biagio and Cesare Arrigo University Hospital, Alessandria, Italy
3Department of Information Engineering, Università di Padova, Padova, Italy
4IRCCS Ospedale Policlinico San Martino, Genoa, Italy
5Department of Health Science (DISSAL), University of Genoa, Genoa (GE), Italy
6Neuroradiology Unit, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
7Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana., Pisa, Italy
8IMAGO7 Research Foundation, Pisa, Italy
9Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, United States of America
10Helen Wills Neuroscience Institute, University of California, Berkeley, United States of America
Presenting Author: Lorenzo Gualco

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References

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3. Donatelli, G. et al. Motor cortical patterns of upper motor neuron pathology in amyotro-phic lateral sclerosis: A 3 T MRI study with iron-sensitive sequences. Neuroimage Clin 35, (2022). doi:10.1016/j.nicl.2022.103138 [doi]
4. Chen, J., Gong, N. J., Chaim, K. T., Otaduy, M. C. G. & Liu, C. Decompose quantitative su-sceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data. Neuroimage 242, (2021). doi:10.1016/j.neuroimage.2021.118477 [doi]
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7. Schofield, M. A. & Zhu, Y. Fast phase unwrapping algorithm for interferometric applica-tions. Opt Lett 28, 1194–1196 (2003). doi:10.1364/ol.28.001194 [doi]
8. Schweser, F., Deistung, A., Lehr, B. W. & Reichenbach, J. R. Quantitative imaging of in-trinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism? Neuroimage 54, 2789–2807 (2011). doi:10.1016/j.neuroimage.2010.10.070 [doi]
9. Li, W. et al. A method for estimating and removing streaking artifacts in quantitative su-sceptibility mapping. Neuroimage 108, 111–122 (2015). doi:10.1016/j.neuroimage.2014.12.043 [doi]
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http://echo.ismrm.org/p/ISMRM2026/630-01-010