551-03-018 / 551-03-018 ISMRM Abstract

Static and dynamic measures of lateral ventricle volume robustly predict cognitive decline in older adults

Primary: Brain Function and fMRI - fMRI Analysis

Secondary: Neuro - Aging

551-03-018 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1

Keywords: fMRI (resting state) Aging Cognitive Function Lateral ventricle volume

Accepted

Hu Cheng ¹, Daniel P Kennedy¹, Colleen S Hughes¹, Roberto French¹, Anne C Krendl¹

¹Psychological and Brain Sciences, Indiana University, Bloomington, United States of America

Presenting Author: Hu Cheng

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References

1. 1 Vonk, J., Ghaznawi, R., Zwartbol, M., Stern, Y. & Geerlings, M. UCC-SMART-Study Group. The role of cognitive and brain reserve in memory decline and atrophy rate in mid and late-life: The SMART-MR study. Cortex 148, 204-214 (2022). doi: 10.1016/j.cortex.2021.11.022. 2 Nestor, S. et al. Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database. Brain 131, 2443-2454 (2008). doi: 10.1093/brain/awn146. 3 Cheng, H. & Kennedy, D. Temporal fluctuation in lateral ventricle volume and its coupling with CSF inflow and global BOLD signal. Sci Rep 15, 30537 (2025). doi: 10.1038/s41598-025-15842-8 4 Weintraub, S. et al. Version 3 of the Alzheimer Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32, 10-17 (2018). doi: 10.1097/WAD.0000000000000223 5 Billot, B. et al. SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining. Med Image Anal 86, 102789 (2023). doi: 10.1016/j.media.2023.102789 6 Krämer, C. et al. Prediction of cognitive performance differences in older age from multimodal neuroimaging data. Geroscience 46, 283-308 (2024). doi: 10.1007/s11357-023-00831-4. [doi]

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http://echo.ismrm.org/p/ISMRM2026/551-03-018