Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-04-009 ISMRM Abstract

Enhanced Excitatory Neuronal Activity in the Valproate Mouse Model of Autism Spectrum Disorder: A ¹H-[¹³C]-NMR Study

Primary: Neuro - Psychiatric Disorders
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
666-04-009 · Neuroimaging of Brain Development from Fetal Life Through Adolescence: Structure, Function, and Prediction · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row G
Keywords: Glucose metabolism Gamma-aminobutyric acid Glutamate Neurodevelopmental disorder 13C-glucose
Accepted
Vimala K Paila1, Anant B Patel 2
1NMR Microimaging and Spectroscopy, CSIR - Center for Cellular and Molecular Biology, Hyderabad, India
2NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India
Presenting Author: Anant B Patel

Synopsis

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References

1. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596 [doi]
2. Toczylowska, B., Zieminska, E., Polowy, R., Olszynski, K. H., & Lazarewicz, J. W. (2022). NMR-Based Metabolomics of Rat Hippocampus, Serum, and Urine in Two Models of Autism. Molecular Neurobiology, 59(9), 5452–5475. https://doi.org/10.1007/s12035-022-02912-5 [doi]
3. Fereshetyan, K., Chavushyan, V., Danielyan, M., & Yenkoyan, K. (2021). Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder. Scientific Reports, 11(1), 23471. https://doi.org/10.1038/s41598-021-02994-6 [doi]
4. Veeraiah, P., Noronha, J. M., Maitra, S., Bagga, P., Khandelwal, N., Chakravarty, S., Kumar, A., & Patel, A. B. (2014). Dysfunctional Glutamatergic and γ-Aminobutyric Acidergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biological Psychiatry, 76(3), 231–238. https://doi.org/10.1016/j.biopsych.2013.09.024 [doi]
5. Kim Hyopil, Chae-Seok Lim, and Bong-Kiun Kaang. (2016). Neuronal Mechanisms and Circuits Underlying Repetitive Behaviors in Mouse Models of Autism Spectrum Disorder. Behavioral and Brain Functions 12. https://doi.org/10.1186/s12993-016-0087-y. [doi]
6. Gould, T. D., Dao, D. T. & Kovacsics, C. E. The Open Field Test. in Mood and Anxiety Related Phenotypes in Mice (ed. Gould, T. D.) vol. 42 1–20 (Humana Press, 2009).
7. De Graaf RA, Brown PB, Mason GF, Rothman DL, Behar KL. Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy. Magn Reson Med. 2003 Jan;49(1):37-46. doi: 10.1002/mrm.10348. PMID: 12509818. [doi] [pmid]
8. Tiwari V, Ambadipudi S, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J Cereb Blood Flow Metab. 2013 Oct;33(10):1523-31. doi: 10.1038/jcbfm.2013.114. Epub 2013 Jul 10. PMID: 23838829; PMCID: PMC3790929. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-04-009