Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
364-05-004 ISMRM Abstract

White matter alteration mediated the association between ventricular dilation and cognitive decline in hydrocephalus patients

Primary: Neuro - Hydrocephalus
Secondary: Diffusion - DWI/DTI/DKI
364-05-004 · Classification in Diffusion MRI I · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row E
Keywords: White Matter Diffusion Tensor Imaging Cognitive impairment Idiopathic normal pressure hydrocephalus
Accepted
Yawen Xiao 1, Jiankun Dai2, Xinlan Xiao1
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, China
2MR Research, Beijing, China
Presenting Author: Yawen Xiao

Synopsis

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References

1. Figueiredo MVDA, Alexiou G, Laube KAC, et al. Novel concepts in the pathogenesis of hydrocephalus. Childs Nerv Syst. 2023, 39:1245-1252. doi:10.1007/s00381-023-05891-7. [doi]
2. Zhang M, Hu X, Wang L. A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus. Neurochem Res. 2024, 49:1123-1136.doi:10.1007/s11064-024-04113-z. [doi]
3. Xiao H, Hu F, Ding J, et al. Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus. Neurosci Bull. 2022, 38:1085-1096. doi:10.1007/s12264-022-00873-2. [doi]
4. Kanno S, Abe N, Saito M, et al. White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study. J Neurol. 2011, 258:1949-1957. doi: 10.1007/s00415-011-6038-5 [doi]
5. Del Bigio MR, Wilson MJ, Enno T. Chronic hydrocephalus in rats and humans: white matter loss and behavior changes. Ann Neurol. 2003, 53:337-346.doi:10.1002/ana.10453. [doi]
6. Tang Y, Yuan X, Duan J, et al. White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study. Front Neurosci. 2021, 15. doi:10.3389/fnins.2021.774638. [doi]
7. Kanno S, Ogawa K-i, Kikuchi H, et al. Reduced default mode network connectivity relative to white matter integrity is associated with poor cognitive outcomes in patients with idiopathic normal pressure hydrocephalus. BMC Neurol. 2021, 21. doi: 10.1186/s12883-021-02389-0. [doi]
8. Fox RJ, Sakaie K, Lee JC, et al. A validation study of multicenter diffusion tensor imaging: reliability of fractional anisotropy and diffusivity values. AJNR. 2012, 33:695-700.doi:10.3174/ajnr.A2844. [doi]
9. de Groot M, Verhaaren BF, de Boer R, et al. Changes in normal-appearing white matter precede development of white matter lesions. Stroke. 2013, 44:1037-1042.doi:10.1161/STROKEAHA.112.680223. [doi]
10. Hannawi Y, Vaidya D, Yanek LR, et al. Association Of Vascular Properties With The Periventricular And Deep White Matter Hyperintensity In Middle-age Population. Stroke. 2022, 53.doi:10.1161/str.53.suppl_1.WP14. [doi]
11. Baykara E, Gesierich B, Adam R, et al. A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms. Ann Neurol. 2016, 80:581-592.doi:10.1002/ana.24758. [doi]

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http://echo.ismrm.org/p/ISMRM2026/364-05-004