Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-04-012 ISMRM Abstract

Hyperpolarized 129Xe MRI in Pediatric Hematopoietic Stem Cell Transplant with and without Bronchiolitis Obliterans Syndrome

Primary: Body - Lung
Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)
468-04-012 · Pediatric Cardiopulmonary MRI · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row I
Keywords: Pediatric Hyperpolarized 129Xe MRI Lung MRI Ventilation Xenon
Accepted
Brandon Zanette1, Faiyza S Alam1,2, Felix Ratjen1, Tal Schecter3, Joerg Krueger3, Giles E Santyr 1,2
1Translational Medicine Program, The Hospital for Sick Children, Toronto, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, Canada
3Division of Haematology-Oncology, The Hospital for Sick Children, Toronto, Canada
Presenting Author: Giles E Santyr

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References

1. Tamburro RF, Cooke KR, Davies SM, et al. Pulmonary Complications of Pediatric Hematopoietic Cell Transplantation A National Institutes of Health Workshop Summary. Ann. Am. Thorac. Soc. 2021;18:381–394 doi: 10.1513/AnnalsATS.202001-006OT. [doi]
2. Shanthikumar S, Gower WA, Cooke KR, et al. Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink? Transplant. Cell. Ther. 2024;30:760–769 doi: 10.1016/j.jtct.2024.05.012. [doi]
3. Walkup LL, Myers K, El-Bietar J, et al. Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry. Eur. Respir. J. 2019;53:1801779 doi: 10.1183/13993003.01779-2018. [doi]
4. Jagasia MH, Greinix HT, Arora M, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol. Blood Marrow Transplant. 2015;21:389-401.e1 doi: 10.1016/j.bbmt.2014.12.001. [doi]
5. Graham BL, Steenbruggen I, Barjaktarevic IZ, et al. Standardization of spirometry 2019 update an official American Thoracic Society and European Respiratory Society technical statement. Am. J. Respir. Crit. Care Med. 2019;200:E70–E88 doi: 10.1164/rccm.201908-1590ST. [doi]
6. Robinson PD, Latzin P, Verbanck S, et al. Consensus statement for inert gas washout measurement using multiple- and single- breath tests. Eur. Respir. J. 2013;41:507–522 doi: 10.1183/09031936.00069712. [doi]
7. Bdaiwi AS, Willmering MM, Plummer JW, et al. <scp> 129 Xe </scp> Image Processing Pipeline: An open‐source, graphical user interface application for the analysis of <scp> hyperpolarized 129 Xe MRI </scp>. Magn. Reson. Med. 2025;93:1220–1237 doi: 10.1002/mrm.30347. [doi]
8. He M, Driehuys B, Que LG, Huang YCT. Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. Acad. Radiol. 2016;23:1521–1531 doi: 10.1016/j.acra.2016.07.014. [doi]
9. Smith LJ, Collier GJ, Marshall H, et al. Patterns of regional lung physiology in cystic fibrosis using ventilation magnetic resonance imaging and multiple-breath washout. Eur. Respir. J. 2018;52:1–12 doi: 10.1183/13993003.00821-2018. [doi]
10. Kanhere N, Couch MJ, Kowalik K, et al. Correlation of Lung Clearance Index with Hyperpolarized 129 Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 2017;196:1073–1075 doi: 10.1164/rccm.201611-2228LE. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-04-012