Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-01-013 ISMRM Abstract

Single-acquisition MP2RAGE at 7T for synthetic multi-contrast generation in multiple sclerosis

Primary: Neuro - Multiple Sclerosis
Secondary: Contrast Mechanisms - Multi-Contrast
668-01-013 · Molecular Imaging and Ultra High Field Acquisition · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row I
Keywords: Multi-Contrast Multiple Sclerosis 7T MP2RAGE Synthetic contrasts
Accepted
Myrte Strik 1,2,3, Matthijs de Buck1,3,4, Emma Brouwer1,3, Nikos Priovoulos5, Mark Wessels6, Eva Strijbis6, Frederik Barkhof7, Menno Schoonheim2, Wietske van der Zwaag1,3
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands
2Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam, Netherlands
3Computational Cognitive Neuroscience & Neuroimaging, Royal Netherlands Academy for Arts and Sciences, Netherlands Institute for Neuroscience, Amsterdam, Netherlands
4Department of Neurosurgery, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
5Nuffield Department of Clinical Neurosciences, Centre for Integrative Neuroimaging, FMRIB Centre, University of Oxford, Oxford, United Kingdom
6Neurology, MS Center Amsterdam, Amsterdam, Netherlands
7UCL Hawkes Institute, University College London, London, United Kingdom
Presenting Author: Myrte Strik

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References

1. Marques, J. P. et al. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T 1-mapping at high field. Neuroimage 49, 1271–1281 (2010). https://doi.org/10.1016/j.neuroimage.2009.10.002 [doi]
2. Priovoulos, N., Andersen, M., Dumoulin, S. O., Boer, V. O. & van der Zwaag, W. High-Resolution Motion-corrected 7.0-T MRI to Derive Morphologic Measures from the Human Cerebellum in Vivo. Radiology 307, (2023). https://doi.org/10.1148/radiol.220989 [doi]
3. Brouwer, E. J. P., van der Zwaag, W., Heij, J. & Priovoulos, N. Easy‐to‐use B1+ shims for human brain imaging at 7 T. Magn Reson Med 94, 2010 (2025). https://doi.org/10.1002/mrm.30617 [doi]
4. Voelker, M. N. et al. The traveling heads: multicenter brain imaging at 7 Tesla. Magnetic Resonance Materials in Physics, Biology and Medicine 29, 399–415 (2016). 10.1007/s10334-016-0541-8 [doi]
5. Middlebrooks, E. H. et al. 7 T Lesion-Attenuated Magnetization-Prepared Gradient Echo Acquisition for Detection of Posterior Fossa Demyelinating Lesions in Multiple Sclerosis. Invest Radiol 59, 513–518 (2024). 10.1097/RLI.0000000000001050 [doi]
6. Kolb, H. et al. 7T MRI Differentiates Remyelinated from Demyelinated Multiple Sclerosis Lesions. https://doi.org/10.1002/ana.26194. [doi]
7. Rooney, W. D. et al. Magnetic Field and Tissue Dependencies of Human Brain Longitudinal 1 H 2 O Relaxation in Vivo. https://doi.org/10.1002/mrm.21122 (2007) doi:10.1002/mrm.21122. [doi]
8. Viessmann, O., Li, L., Benjamin, P. & Jezzard, P. T2-Weighted intracranial vessel wall imaging at 7 Tesla using a DANTE-prepared variable flip angle turbo spin echo readout (DANTE-SPACE). Magn Reson Med 77, 655–663 (2017). 10.1002/mrm.26152 [doi]
9. Schmidt, P. et al. An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis. Neuroimage 59, 3774–3783 (2012). https://doi.org/10.1016/j.neuroimage.2011.11.032 [doi]

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http://echo.ismrm.org/p/ISMRM2026/668-01-013