Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
404-04-008 ISMRM Abstract

Quantitative Susceptibility Mapping Detects Progressive Iron Accumulation in Early MSA

Primary: Neuro - Other Neurodegeneration
Secondary: Neuro - Parkinson's Disease
404-04-008 · Applications of QSM and Iron in the Brain · Tuesday, 12 May, 4:00 PM–5:50 PM · Ballroom East
Keywords: Neurodegeneration Atrophy Quantitative Susceptibility Mapping (QSM) Iron quantification
Accepted
Paula Trujillo 1, Kilian Hett1, Amy Cooper1, Amy E Brown1, Manus J Donahue1, Colin D McKnight2, Margaret Bradbury3, Cynthia Wong3, David Stamler3, Daniel O Claassen1
1Department of Neurology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Radiology and Radiological Science, Vanderbilt University Medical Center, Nashville, United States of America
3Alterity Therapeutics, San Francisco, United States of America
Presenting Author: Paula Trujillo

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References

1. Kaindlstorfer C, Jellinger KA, Eschlböck S, Stefanova N, Weiss G, Wenning GK. The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint. J Alzheimers Dis. 2018;61(4):1253-1273. doi:10.3233/JAD-170601 [doi]
2. Finkelstein DI, Shukla JJ, Cherny RA, et al. The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy. J Parkinsons Dis. 2022;12(1):105-115. doi:10.3233/JPD-212877 [doi]
3. Trujillo P, Hett K, Cooper A, et al. The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy. Ann Clin Transl Neurol. 2025;12(9):1823. doi:10.1002/ACN3.70106 [doi]
4. Dymerska B, Eckstein K, Bachrata B, et al. Phase unwrapping with a rapid opensource minimum spanning tree algorithm (ROMEO). Magn Reson Med. 2021;85(4):2294-2308. doi:10.1002/MRM.28563 [doi]
5. Liu Z, Spincemaille P, Yao Y, Zhang Y, Wang Y. MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping. Magn Reson Med. 2018;79(5):2795-2803. doi:10.1002/MRM.26946 [doi]
6. Xiao Y, Fonov V, Chakravarty MM, et al. A dataset of multi-contrast population-averaged brain MRI atlases of a Parkinson׳s disease cohort. Data Brief. 2017;12:370. doi:10.1016/J.DIB.2017.04.013 [doi]
7. Lancione M, Cencini M, Costagli M, et al. Diagnostic accuracy of quantitative susceptibility mapping in multiple system atrophy: The impact of echo time and the potential of histogram analysis. Neuroimage Clin. 2022;34:102989. doi:10.1016/J.NICL.2022.102989 [doi]
8. Wenning GK, Tison F, Seppi K, et al. Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Movement Disorders. 2004;19(12):1391-1402. doi:10.1002/mds.20255 [doi]

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http://echo.ismrm.org/p/ISMRM2026/404-04-008