Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-01-003 ISMRM Abstract

Simultaneous Anatomical Imaging and Metabolic Measurements Using Interleaved 1H-MRI/31P-MRS

Primary: Acquisition & Reconstruction - Pulse Sequence Design: Neuro
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
362-01-003 · Neuro Sequences, Applications, and Traveling Phantoms · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row C
Keywords: Small animals Brain energy metabolism 31P-MRS Interleaved acquisition 1H-MRI
Accepted
Snow Lin 1, Anbang Chen2, Xin Yu1,3,4
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, United States of America
2Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, United States of America
3Department of Radiology, Case Western Reserve University, Cleveland, United States of America
4Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States of America
Presenting Author: Snow Lin

Synopsis

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References

1. Joo IL, Lam WW, Oakden W, et al. Early alterations in brain glucose metabolism and vascular function in a transgenic rat model of Alzheimer’s disease. Prog Neurobiol. 2022;217:102327. doi:10.1016/j.pneurobio.2022.102327 [doi]
2. Van Dyken P, Lacoste B. Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier. Front Neurosci. 2018;12:930. doi:10.3389/fnins.2018.00930 [doi]
3. Mitra S, Banik A, Saurabh S, Maulik M, Khatri SN. Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders. J Neurosci. 2022;42(10):1888-1907. doi:10.1523/JNEUROSCI.0998-21.2022 [doi]
4. Jett S, Boneu C, Zarate C, et al. Systematic review of 31P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer’s disease. Front Aging Neurosci. 2023;15:1183228. doi:10.3389/fnagi.2023.1183228 [doi]
5. Wang J, He L, Zheng H, Lu ZL. Improving structural brain images acquired with the 3D FLASH sequence. Magn Reson Imaging. 2017;38:224-232. doi:10.1016/j.mri.2017.01.014 [doi]
6. Sørensen OW. The generalized Ernst angle. Journal of Magnetic Resonance Open. 2024;19:100148. doi:10.1016/j.jmro.2024.100148 [doi]
7. Kim K, Li Y, Koch LG, Liang ZP, Yu X. Altered Acute Metabolic Response to Muscle Stimulation in Muscular Dystrophic Mice Observed by Phosphorus-31 Magnetic Resonance Spectroscopy and Fingerprinting. J Appl Physiol (1985). 2025;139(3):628-637. doi:10.1152/japplphysiol.00185.2025 [doi]

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http://echo.ismrm.org/p/ISMRM2026/362-01-003