463-04-010 ISMRM Abstract

Investigating the relationship between axon microstructure and sodium ion signal using 1H diffusion MRI and 23Na-MRI

Primary: Diffusion - Microstructure

Secondary: Neuro - White Matter

463-04-010 · Advanced Microstructural Imaging of White Matter and Traumatic Brain Injury · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row D

Keywords: Sodium MRI Diffusion Microstructure Intracellular and extracellular sodium

Accepted

Alaleh Alivar^1,2, Santiago Coelho ^1,2, Sohae Chung^1,2, Ying-Chia Lin^1,2, Mary T Bruno^1,2, Justin Quimbo¹, Georg Schramm³, Els Fieremans^1,2, Dmitry S Novikov^1,2, Yongxian Qian^1,2, Fernando E Boada^4,5, Yvonne W Lui^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America

²Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America

³Nuclear Medicine, KU Leuven, Leuven, Belgium

⁴Department of Radiology, Stanford University, Stanford, United States of America

⁵Radiology, Stanford Medicine, Stanford, United States of America

Presenting Author: Santiago Coelho

Synopsis

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References

1. Burnier, M., Sodium in health and disease. 2007: CRC press. [https://doi.org/10.3109/9781420020946] [doi]

2. Novikov, D.S., et al., Rotationally-invariant mapping of scalar and orientational metrics of neuronal microstructure with diffusion MRI. NeuroImage, 2018. 174: p. 518-538. [ https://doi.org/10.1016/j.neuroimage.2018.03.006] [doi]

3. Coelho, S., et al., Reproducibility of the Standard Model of diffusion in white matter on clinical MRI systems. Neuroimage, 2022. 257: p. 119290. [https://doi.org/10.1016/j.neuroimage.2022.119290] [doi]

4. Boada, F.E., et al., Fast three dimensional sodium imaging. Magnetic resonance in medicine, 1997. 37(5): p. 706-715. [ https://doi.org/10.1002/mrm.1910370512] [doi]

5. Qian, Y., V.A. Stenger, and F.E. Boada, Parallel imaging with 3D TPI trajectory: SNR and acceleration benefits. Magnetic resonance imaging, 2009. 27(5): p. 656-663. [https://doi.org/10.1016/j.mri.2008.10.008] [doi]

6. Fischl, B., FreeSurfer. Neuroimage, 2012. 62(2): p. 774-81. [https://doi.org/10.1016/j.neuroimage.2012.01.021] [doi]

7. Alivar, A., et al., Mapping regional brain total sodium concentration - using anatomically- guided reconstruction of dual echo Sodium-23 MRI: moving toward improved accuracy and precision. AJNR Am J Neuroradiol, 2025. [https://doi.org/10.3174/ajnr.A8984] [doi]

8. Madelin, G., et al., Sodium MRI: methods and applications. Progress in nuclear magnetic resonance spectroscopy, 2014. 79: p. 14-47.[ https://doi.org/10.1016/j.pnmrs.2014.02.001] [doi]

9. Schramm, G., et al., Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction. Magnetic Resonance in Medicine, 2023. [ https://doi.org/10.1002/mrm.29936] [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-04-010