Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-01-013 ISMRM Abstract

A WEPCAST-based Investigation: Blood-Brain Barrier Permeability and Cognitive Impairment in Type 1 Narcolepsy

Primary: Neuro - Other Neurodegeneration
Secondary: Brain Function and fMRI - fMRI Analysis
468-01-013 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I
Keywords: MRI Water exchange Blood-brain barrier Narcolepsy
Accepted
Yanjie Zhou 1, Chen Zhang2, Zixuan Lin3, Bing Yu1
1Radiology, Shengjing Hospital of China Medical University, Shenyang, China
2MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China
3College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
Presenting Author: Yanjie Zhou

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Latorre, Daniela, Ulf Kallweit, Eric Armentani, et. 《T Cells in Patients with Narcolepsy Target Self-Antigens of Hypocretin Neurons》. Nature 562, No. 7725 (2018): 63～68.
2. Khajavi, Leila, Xuan-Hung Nguyen, Clémence Queriault, et. 《The Transcriptomics Profiling of Blood CD4 and CD8 T-Cells in Narcolepsy Type I》. Frontiers in Immunology 14 (2023/11): 1249405.
3. Moresco, Monica, Concetta Valentina Tropeano, Martina Romagnoli, et. 《Elevated Circulating Cell-Free Mitochondrial DNA Level in Cerebrospinal Fluid of Narcolepsy Type 1》. Brain Communications 7, No. 2 (2025): fcaf125.
4. Lin, Zixuan, Sandeepa Sur, Peiying Liu, et. 《Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease》. Annals of Neurology 90, No. 2 (2021): 227～38.
5. Montagne, Axel, Daniel A. Nation, Abhay P. Sagare, et. 《APOE4 Leads to Blood–Brain Barrier Dysfunction Predicting Cognitive Decline》. Nature 581, No. 7806 (2020): 71～76.
6. Lin, Zixuan, Yang Li, Pan Su, et. 《Non‐contrast MR Imaging of Blood‐brain Barrier Permeability to Water》. Magnetic Resonance in Medicine 80, No. 4 (2018): 1507～20.
7. Kadry, Hossam, Behnam Noorani和Luca Cucullo. 《A Blood–Brain Barrier Overview on Structure, Function, Impairment, and Biomarkers of Integrity》. Fluids and Barriers of the CNS 17, No. 1 (2020): 69.
8. Dauvilliers, Yves, Isabelle Jaussent, Michel Lecendreux, et. 《Cerebrospinal Fluid and Serum Cytokine Profiles in Narcolepsy with Cataplexy: A Case-Control Study》. Brain, Behavior, and Immunity 37 (2014/3): 260～66.
9. Khajavi, Leila, Xuan-Hung Nguyen, Clémence Queriault, et. 《The Transcriptomics Profiling of Blood CD4 and CD8 T-Cells in Narcolepsy Type I》. Frontiers in Immunology 14 (2023/11): 1249405.
10. Nation DA et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat. Med 25, 270–276 (2019). [PubMed: 30643288] [pmid]
11. Montagne, Axel, Daniel A. Nation, Abhay P. Sagare, et. 《APOE4 Leads to Blood–Brain Barrier Dysfunction Predicting Cognitive Decline》. Nature 581,No. 7806 (2020): 71～76.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-01-013