Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-03-004 / 552-03-004 ISMRM Abstract

AI-Enhanced FOD Reveals Structural Connectivity Changes Associated with Neuropsychological Function in Multiple Sclerosis

Primary: Diffusion - Diffusion Analysis & Visualization
Secondary: Analysis Methods - Image Enhancement
552-03-004 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
552-03-004 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
Keywords: Multiple Sclerosis Image enhacement Diffusion-weighted imaging (DWI) Fibre Orientation Distribution Neuropsychology
Accepted
Zihao Tang1,2,3, Xinyi Wang3, Kyi Nue Nyo Zin4, Dongang Wang1,4,5, Heidi Beadnall4, Weidong Cai3, Chenyu Wang 1,4, Michael Barnett1,4
1Brain and Mind Centre, The University of Sydney, Sydney, Australia
2Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
3School of Computer Science, Faculty of Engineering, The University of Sydney, Sydney, Australia
4Sydney Neuroimaging Analysis Centre, Camperdown, Australia
5Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
Presenting Author: Chenyu Wang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Tournier, J. D., Smith, R., Raffelt, D., Tabbara, R., Dhollander, T., Pietsch, M., Christiaens, D., Jeurissen, B., Yeh, C.H., & Connelly, A. (2019). MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage, 202, 116137. https://doi.org/10.1016/j.neuroimage.2019.116137 [doi]
2. Tournier, J. D., Calamante, F., & Connelly, A. (2010). Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions. Proceedings of the International Society for Magnetic Resonance in Medicine, 2010, 1670. https://archive.ismrm.org/2010/1670.html
3. Smith, R. E., Tournier, J. D., Calamante, F., & Connelly, A. (2015). SIFT2: Enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography. Neuroimage, 119, 338-351. https://doi.org/10.1016/j.neuroimage.2015.06.092 [doi]
4. Tournier, J. D., Calamante, F., & Connelly, A. (2007). Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage, 35(4), 1459-1472. https://doi.org/10.1016/j.neuroimage.2007.02.016 [doi]
5. Wang, X., Barnett, M., Boonstra, F., Barnett, Y., Cabezas, M., D'Souza, A., ... & Wang, C. (2025). From Promise to Practical Reality: Transforming Diffusion MRI Analysis with Fast Deep Learning Enhancement. arXiv preprint arXiv:2508.10950.
6. Benton, A. L., Hamsher, D. S., & Sivan, A. B. (1994). Controlled oral word association test. Archives of Clinical Neuropsychology.
7. Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2000). California verbal learning test–second edition. New York: Psychological Corporation.
8. Benedict, R. H. (1997). Brief visuospatial memory test--revised. PAR.
9. Gronwall, D. M. A. (1977). Paced auditory serial-addition task: a measure of recovery from concussion. Perceptual and motor skills, 44(2), 367-373.
10. Smith, A. (1973). Symbol digit modalities test. The clinical neuropsychologist.
11. Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive function system. Assessment.
12. Benedict, R. H., Bruce, J. M., Dwyer, M. G., Abdelrahman, N., Hussein, S., Weinstock-Guttman, B., Garg, N., Munschauer, F. & Zivadinov, R. (2006). Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Archives of neurology, 63(9), 1301-1306.
13. Benedict, R. H., Amato, M. P., DeLuca, J., & Geurts, J. J. (2020). Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues. The Lancet Neurology, 19(10), 860-871. https://doi.org/10.1016/S1474-4422(20)30277-5 [doi]
14. Jenkins, T. M., Ciccarelli, O., Atzori, M., Wheeler-Kingshott, C. A. M., Miller, D. H., Thompson, A. J., & Toosy, A. T. (2011). Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 82(9), 1017-1021. https://doi.org/10.1136/jnnp.2010.239715 [doi]
15. Llufriu, S., Martinez-Heras, E., Solana, E., Sola-Valls, N., Sepulveda, M., Blanco, Y., Martinez-Lapiscina, E.H., Andorra, M., Villoslada, P., Prats-Galino, A. & Saiz, A. (2017). Structural networks involved in attention and executive functions in multiple sclerosis. NeuroImage: Clinical, 13, 288-296. https://doi.org/10.1016/j.nicl.2016.11.026 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-03-004