Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-04-007 ISMRM Abstract

MRI Biomarkers and Circulating Tumor DNA Kinetics for Evaluating Cancer Therapy Response

Primary: Diffusion - Diffusion Modeling
Secondary: Analysis Methods - Data Processing
563-04-007 · Diffusion MRI and Other Modalities · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Treatment Response Apparent diffusion coefficient Tumor volume Circulating tumor DNA (ctDNA) Oropharyngeal cancer
Accepted
Ramesh Paudyal 1, Bill H Diplas2, David N Brown3, Vaios Hatzoglou4, Britta Weigelt3, Nancy Lee2, Nadeem Riaz2, Amita Shukla-Dave1,4
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, United States of America
2Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, United States of America
3Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America
Presenting Author: Ramesh Paudyal

Synopsis

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References

1. 1. Paudyal R, Grkovski M, Oh JH, et al. Application of Community Detection Algorithm to Investigate the Correlation between Imaging Biomarkers of Tumor Metabolism, Hypoxia, Cellularity, and Perfusion for Precision Radiotherapy in Head and Neck Squamous Cell Carcinomas. Cancers (Basel). Aug 3 2021;13(15)doi:10.3390/cancers13153908 [doi]
2. 2. Riaz N, Sherman E, Pei X, et al. Precision Radiotherapy: Reduction in Radiation for Oropharyngeal Cancer in the 30 ROC Trial. J Natl Cancer Inst. Jun 1 2021;113(6):742-751. doi:10.1093/jnci/djaa184 [doi]
3. 3. Huttinger ZM, Gogineni E, Baliga S, et al. Circulating tumor DNA determines induction chemotherapy response in HPV associated oropharyngeal squamous cell carcinoma: A pilot study. Oral Oncol. Feb 2025;161:107179. doi:10.1016/j.oraloncology.2025.107179 [doi]
4. 4. Thoeny HC, De Keyzer F, King AD. Diffusion-weighted MR imaging in the head and neck. Radiology. Apr 2012;263(1):19-32. doi:10.1148/radiol.11101821 [doi]
5. 5. Magbanua MJM, Li W, Wolf DM, et al. Circulating tumor DNA and magnetic resonance imaging to predict neoadjuvant chemotherapy response and recurrence risk. NPJ Breast Cancer. Mar 25 2021;7(1):32. doi:10.1038/s41523-021-00239-3 [doi]
6. 6. Bleckman RF, Haag C, Rifaela N, et al. Levels of circulating tumor DNA correlate with tumor volume in gastro-intestinal stromal tumors: an exploratory long-term follow-up study. Mol Oncol. Nov 2024;18(11):2658-2667. doi:10.1002/1878-0261.13644 [doi]
7. 7. Ruiz-Torres DA, Merkin RD, Bryan ME, et al. Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer. npj Precision Oncology. 2025/08/22 2025;9(1):298. doi:10.1038/s41698-025-01084-4 [doi]
8. 8. Cao Y, Haring CT, Brummel C, et al. Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma. Clin Cancer Res. Jan 15 2022;28(2):350-359. doi:10.1158/1078-0432.Ccr-21-2338 [doi]

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http://echo.ismrm.org/p/ISMRM2026/563-04-007