Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
470-11-159 ISMRM Abstract

Time-Resolved Glutamate Dynamics During Working Memory

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
470-11-159 · Spectroscopy Traditional Posters · Tuesday, 12 May, 4:55 PM–5:50 PM · Traditional Posters | Exhibition Hall
Keywords: Spectroscopy Functional spectroscopy Glutamate 1H MRS Working memory
Accepted
Daniel J Cocking 1, Ryan Elson2, Katherine Dyke2, Mohammad Z Katshu3,4, Claudia Danielmeier2, Adam P Berrington1
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
2School of Psychology, University of Nottingham, Nottingham, United Kingdom
3School of Medicine, University of Nottingham, Nottingham, United Kingdom
4Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, United Kingdom
Presenting Author: Daniel J Cocking

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Mangia S, Tkáč I, Gruetter R, Van De Moortele PF, Maraviglia B, Uǧurbil K. Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex. Journal of Cerebral Blood Flow and Metabolism. 2007;27(5):1055-1063. doi:10.1038/SJ.JCBFM.9600401 [doi]
2. Chen C, Sigurdsson HP, Pépés SE, et al. Activation induced changes in GABA: Functional MRS at 7 T with MEGA-sLASER. Neuroimage. 2017;156:207-213. doi:10.1016/J.NEUROIMAGE.2017.05.044 [doi]
3. Bell T, Boudes ES, Loo RS, et al. In vivo Glx and Glu measurements from GABA-edited MRS at 3 T. NMR Biomed. 2021;34(5):e4245. doi:10.1002/NBM.4245 [doi]
4. Stanley JA, Raz N. Functional magnetic resonance spectroscopy: The “new” MRS for cognitive neuroscience and psychiatry research. Front Psychiatry. 2018;9(MAR):311698. doi:10.3389/FPSYT.2018.00076/BIBTEX [doi]
5. Mullins PG. Towards a theory of functional magnetic resonance spectroscopy (fMRS): A meta‐analysis and discussion of using MRS to measure changes in neurotransmitters in real time. Scand J Psychol. 2018;59(1):91-103. doi:10.1111/SJOP.12411 [doi]
6. Koolschijn RS, Shpektor A, Clarke WT, et al. Memory recall involves a transient break in excitatory-inhibitory balance. Elife. 2021;10. doi:10.7554/eLife.70071 [doi]
7. Jelen, L. A., King, S., Horne, C. M., Lythgoe, D. J., Young, A. H., & Stone, J. M. (2019). Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 29(2), 222–234. doi: 10.1016/j.euroneuro.2018.12.005 [doi]
8. Finkelman T, Furman-Haran E, Paz R, Tal A. Quantifying the excitatory-inhibitory balance: A comparison of SemiLASER and MEGA-SemiLASER for simultaneously measuring GABA and glutamate at 7T. Neuroimage. 2022;247:118810. doi:10.1016/j.neuroimage.2021.118810 [doi]
9. Kamiński, J., Sullivan, S., Chung, J. M., Ross, I. B., Mamelak, A. N., & Rutishauser, U. (2017). Persistently active neurons in human medial frontal and medial temporal lobe support working memory. Nature neuroscience, 20(4), 590–601. https://doi.org/10.1038/nn.4509 [doi]
10. Clarke WT, Ligneul C, Cottaar M, Ip IB, Jbabdi S. Universal dynamic fitting of magnetic resonance spectroscopy. Magn Reson Med. 2024;91(6):2229-2246. doi:10.1002/mrm.30001 [doi]
11. Stanley JA, Burgess A, Khatib D, Ramaseshan K, Arshad M, Wu H, Diwadkar VA, 2017. Functional dynamics of hippocampal glutamate during associative learning assessed with in vivo 1 H functional magnetic resonance spectroscopy. NeuroImage. doi: 10.1016/j.neuroimage.2017.03.051 [doi]
12. Craven, A. R., Dwyer, G., Ersland, L., Kazimierczak, K., Noeske, R., Sandøy, L. B., Johnsen, E., & Hugdahl, K. (2024). GABA, glutamatergic dynamics and BOLD contrast assessed concurrently using functional MRS during a cognitive task. NMR in biomedicine, 37(3), e5065. doi:10.1002/nbm.5065 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/470-11-159