Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-03-002 ISMRM Abstract

Leveraging Diffusion MRI to Detect Heterogeneous Fiber Remodeling in Simulated Skeletal Muscle

Primary: Diffusion - Diffusion Modeling
Secondary: Musculoskeletal - Muscle
367-03-002 · Muscle Microstructure and Deformation · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row H
Keywords: Simulations Skeletal Muscle Stimulated Echos Diffusion Tensor Imaging (DTI) Double pulsed field gradient
Accepted
David B Berry 1, Jascha Gaarder1, Vitaly Galinsky2, Samuel R Ward1, Lawrence R Frank3
1Orthopaedic Surgery, University of California, San Diego, United States of America
2University of California, San Diego, United States of America
3Center for Scientific Computation in Imaging, University of California, San Diego, United States of America
Presenting Author: David B Berry

Synopsis

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References

1. Lieber, R. L. Skeletal Muscle Structure, Function, and Plasticity. (Lippincott Williams & Wilkins, 2002).
2. Minamoto V et al. Dramatic changes in muscle contractile and structural properties after 2 botulinum toxin injections. 2015 Muscle & Nerve. DOI: 10.1002/mus.24576. [doi]
3. Le Bihan, D. et al. Diffusion tensor imaging: Concepts and applications. Journal of Magnetic Resonance Imaging 13, 534–546 (2001). DOI: 10.1002/jmri.1076 [doi]
4. Berry, D. B., Gordon III, J. A., Adair, V., Frank, L. R. & Ward, S. R. From Voxels to Physiology: A Review of Diffusion Magnetic Resonance Imaging Applications in Skeletal Muscle. Journal of Magnetic Resonance Imaging 61, 595–615 (2025). DOI: 10.1002/jmri.29489 [doi]
5. Lukacs, E. A Characterization of the Gamma Distribution. The Annals of Mathematical Statistics 26, 319–324 (1955).
6. Balls, G. T. & Frank, L. R. A simulation environment for diffusion weighted MR experiments in complex media. Magn Reson Med 62, 771–778 (2009). DOI: 10.1002/mrm.22033 [doi]
7. Berry, D. B., Regner, B., Galinsky, V., Ward, S. R. & Frank, L. R. Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle. Magnetic Resonance in Med 80, 317–329 (2018). DOI: 10.1002/mrm.26993 [doi]
8. Berry, D. B., Englund, E. K., Galinsky, V., Frank, L. R. & Ward, S. R. Varying diffusion time to discriminate between simulated skeletal muscle injury models using stimulated echo diffusion tensor imaging. Magnetic Resonance in Medicine 85, 2524–2536 (2021). DOI: 10.1002/mrm.28598 [doi]
9. McDowell, A. R., Feiweier, T., Muntoni, F., Hall, M. G. & Clark, C. A. Clinically feasible diffusion MRI in muscle: Time dependence and initial findings in Duchenne muscular dystrophy. Magnetic Resonance in Medicine 86, 3192–3200 (2021). DOI: 10.1002/mrm.28945 [doi]
10. Berry, D. B. et al. Double pulsed field gradient diffusion MRI to assess skeletal muscle microstructure. Magnetic Resonance in Medicine 90, 1582–1593 (2023). DOI: 10.1002/mrm.29751 [doi]
11. Frank, L. R., Zahneisen, B. & Galinsky, V. L. JEDI: Joint Estimation Diffusion Imaging of macroscopic and microscopic tissue properties. Magn Reson Med 84, 966–990 (2020). DOI: 10.1002/mrm.28141 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-03-002