367-02-007 ISMRM Abstract

ADC and Native T1 Mapping Histogram Analyses Reveal Tumor Proliferation and Microenvironment in Neuroblastoma

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods

Secondary: Pediatrics - Cancer

367-02-007 · Cancer Detection and Therapies · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row H

Keywords: Apparent diffusion coefficient Neuroblastoma Native T1 mapping Tumor microenvironment Cell proliferation

Accepted

Haoru Wang ¹, Xiang Cheng¹, Qian Hu¹, Lisha Nie², Weiyi Zhu¹, Yingxue Tong¹, Xin Chen¹, Ling He¹, Huiru Zhu¹, Jie Huang¹, Jiaxin Su¹, Ceng Zeng¹, Jinhua Cai¹

¹Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China

²GE Healthcare, MR Research China, Beijing, China

Presenting Author: Haoru Wang

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References

1. Irwin, M.S.; Goldsmith, K.C. Current and Emerging Biomarkers: Impact on Risk Stratification for Neuroblastoma. Journal of the National Comprehensive Cancer Network : JNCCN 2024, 22, doi:10.6004/jnccn.2024.7051. [doi]

2. Horwacik, I. The Extracellular Matrix and Neuroblastoma Cell Communication-A Complex Interplay and Its Therapeutic Implications. Cells 2022, 11, doi:10.3390/cells11193172. [doi]

3. Tadeo, I.; Berbegall, A.P.; Castel, V.; García-Miguel, P.; Callaghan, R.; Påhlman, S.; Navarro, S.; Noguera, R. Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort. British journal of cancer 2016, 115, 480-489, doi:10.1038/bjc.2016.210. [doi]

4. Wang, H.; Cai, J. Quantitative MRI in Childhood Neuroblastoma: Beyond the Assessment of Image-defined Risk Factors. Radiology. Imaging cancer 2024, 6, e240089, doi:10.1148/rycan.240089. [doi]

5. Jamin, Y.; Tucker, E.R.; Poon, E.; Popov, S.; Vaughan, L.; Boult, J.K.; Webber, H.; Hallsworth, A.; Baker, L.C.; Jones, C.; et al. Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma. Radiology 2013, 266, 130-140, doi:10.1148/radiol.12120128. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-02-007