Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-02-002 / 552-02-002 ISMRM Abstract

T1 mapping Based on 3D SPACE Shows the Transfer of Oxygen into Cerebrospinal Fluid during Hyperoxia in the Healthy Brain

Accepted
Emma Biondetti1,2, Davide Di Censo1,2, Sara Pomante1,2, Stefano Censi1,2, Ekaterina Bliakharskaia1,2, Manuela Carriero1,2, Francesca Graziano1,2, Alessandra Caporale1,2, Antonio M Chiarelli1,2, Richard G Wise 1,2
1Department of Neurosciences, Imaging and Clinical Sciences, University 'G.d'Annunzio' of Chieti-Pescara, Chieti, Italy
2Institute of Advanced Biomedical Technologies, University 'G.d'Annunzio' of Chieti-Pescara, Chieti, Italy
Presenting Author: Richard G Wise

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Agarwal N, Lewis LD, Hirschler L, et al. Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ ISMRM Imaging Neurofluids Study group” Workshop in Rome. Magnetic Resonance Imaging 2024; 59: 431–449. DOI: 10.1002/jmri.28759. [doi]
2. Ohashi T, Naganawa S, Iwata S, et al. Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops. Jpn J Radiol 2021; 39: 433–441. DOI: 10.1007/s11604-020-01079-0. [doi]
3. Naganawa S, Suzuki K, Yamazaki M, et al. Serial Scans in Healthy Volunteers Following Intravenous Administration of Gadoteridol: Time Course of Contrast Enhancement in Various Cranial Fluid Spaces. Magnetic Resonance in Medical Sciences 2014; 13: 7–13. DOI: 10.2463/mrms.2013-0056. [doi]
4. Naganawa S, Ito R, Nakamichi R, et al. Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration. Magn Reson Med Sci 2021; 20: 245–252. DOI: 10.2463/mrms.mp.2020-0062. [doi]
5. Ringstad G, Valnes LM, Dale AM, et al. Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight; 3. Epub ahead of print 26 July 2018. DOI: 10.1172/jci.insight.121537. [doi]
6. Eide PK, Vatnehol SAS, Emblem KE, et al. Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes. Sci Rep 2018; 8: 7194. DOI: 10.1038/s41598-018-25666-4. [doi]
7. Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 2017; 140: 2691–2705. DOI: 10.1093/brain/awx191. [doi]
8. Patel M, Atyani A, Salameh J-P, et al. Safety of Intrathecal Administration of Gadolinium-based Contrast Agents: A Systematic Review and Meta-Analysis. Radiology. Epub ahead of print 28 July 2020. DOI: 10.1148/radiol.2020191373. [doi]
9. Gulani V, Calamante F, Shellock FG, et al. Gadolinium deposition in the brain: summary of evidence and recommendations. The Lancet Neurology 2017; 16: 564–570. DOI: 10.1016/S1474-4422(17)30158-8. [doi]
10. Petitclerc L, Hirschler L, Wells JA, et al. Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans. NeuroImage 2021; 245: 118755. DOI: 10.1016/j.neuroimage.2021.118755. [doi]
11. Zaharchuk G, Martin AJ, Rosenthal G, et al. Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI. Magnetic Resonance in Medicine 2005; 54: 113–121. DOI: 10.1002/mrm.20546. [doi]
12. Zaharchuk G, Busse RF, Rosenthal G, et al. Noninvasive Oxygen Partial Pressure Measurement of Human Body Fluids In Vivo Using Magnetic Resonance Imaging. Academic Radiology 2006; 13: 1016–1024. DOI: 10.1016/j.acra.2006.04.016. [doi]
13. Jiang D, Gou Y, Wei Z, et al. Quantification of T 1 and T 2 of subarachnoid CSF : Implications for water exchange between CSF and brain tissues. Magnetic Resonance in Med 2023; 90: 2411–2419. DOI: 10.1002/mrm.29829. [doi]
14. Biondetti E, Pomante S, Censi S, et al. Three-dimensional T1 measurement in the cerebrospinal fluid using the SPACE-FLAIR sequence. ISMRM 2025; Honolulu, Hawaii, USA, p. 0247.
15. Tancredi FB, Lajoie I, Hoge RD. A simple breathing circuit allowing precise control of inspiratory gases for experimental respiratory manipulations. BMC Research Notes 2014; 7: 235. DOI: 10.1186/1756-0500-7-235. [doi]
16. Marques JP, Kober T, Krueger G, et al. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. NeuroImage 2010; 49: 1271–1281. DOI: 10.1016/j.neuroimage.2009.10.002. [doi]
17. Jenkinson M, Bannister P, Brady M, et al. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002; 17: 825–841. DOI: 10.1016/s1053-8119(02)91132-8. [doi]
18. Jenkinson M, Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal 2001; 5: 143–156. DOI: 10.1016/s1361-8415(01)00036-6. [doi]
19. Jenkinson M, Beckmann CF, Behrens TEJ, et al. FSL. Neuroimage 2012; 62: 782–790. DOI: 10.1016/j.neuroimage.2011.09.015. [doi]
20. Tustison NJ, Cook PA, Holbrook AJ, et al. The ANTsX ecosystem for quantitative biological and medical imaging. Sci Rep 2021; 11: 9068. DOI: 10.1038/s41598-021-87564-6. [doi]
21. Karakuzu A, Boudreau M, Duval T, et al. qMRLab: Quantitative MRI analysis, under one umbrella. JOSS 2020; 5: 2343. DOI: 10.21105/joss.02343. [doi]
22. Yushkevich PA, Piven J, Hazlett HC, et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage 2006; 31: 1116–1128. DOI: 10.1016/j.neuroimage.2006.01.015. [doi]
23. JASP Team. JASP (Version 0.19.3)[Computer software], https://jasp-stats.org/ (2025).
24. Han F, Liu X, Yang Y, et al. Sex-specific age-related differences in cerebrospinal fluid clearance assessed by resting-state functional magnetic resonance imaging. NeuroImage 2024; 302: 120905. DOI: 10.1016/j.neuroimage.2024.120905. [doi]
25. Zhang Y, Zhang R, Ye Y, et al. The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space. Front Aging Neurosci; 13. Epub ahead of print 19 July 2021. DOI: 10.3389/fnagi.2021.693787. [doi]
26. Bhogal AA, Siero JC, Zwanenburg J, et al. Quantitative T1 mapping under precisely controlled graded hyperoxia at 7T. J Cereb Blood Flow Metab 2017; 37: 1461–1469. DOI: 10.1177/0271678X16656864. [doi]
27. Mehemed TM, Fushimi Y, Okada T, et al. Dynamic Oxygen-Enhanced MRI of Cerebrospinal Fluid. PLOS ONE 2014; 9: e100723. DOI: 10.1371/journal.pone.0100723. [doi]

Cite this abstract