Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
604-02-003 ISMRM Abstract

KIVA: Water Exchange Rate (kw) Imaging with Velocity-selective Arterial Spin Labeling

Primary: Neuro - Neurofluids
Secondary: Contrast Mechanisms - Arterial Spin Labelling
604-02-003 · Perfusion, Flow, and Hemodynamics Across Scales · Thursday, 14 May, 1:40 PM–3:30 PM · Ballroom East
Keywords: Water exchange Blood brain barrier Velocity-selective arterial spin labeling Diffusion weighted imaging
Accepted
Chenyang Zhao1, Asmit Ganguly1, Ziyang Huang1, Tanxin Dong1, Zidong Yang1, Xingfeng Shao2,3, Danny J Wang 1
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
2College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Presenting Author: Danny J Wang

Synopsis

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References

1. Wang J, Fernández-Seara MA, Wang S, Lawrence KS. When perfusion meets diffusion: in vivo measurement of water permeability in human brain. Journal of Cerebral Blood Flow & Metabolism. 2007 Apr;27(4):839-49.
2. S. A. Keil, D. Jansson, M. Braun, and J. J. Iliff, “Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal,” Science, vol. 389, no. 6756, p. eadv8269, July 2025, doi: 10.1126/science.adv8269. [doi]
3. X. Shao, C. Zhao, Q. Shou, K. S. St Lawrence, and D. J. J. Wang, “Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling,” Magn Reson Med, vol. 89, no. 5, pp. 1990–2004, May 2023, doi: 10.1002/mrm.29581 [doi]
4. E. C. Wong, M. Cronin, W.-C. Wu, B. Inglis, L. R. Frank, and T. T. Liu, “Velocity-selective arterial spin labeling,” Magn Reson Med, vol. 55, no. 6, pp. 1334–1341, June 2006, doi: 10.1002/mrm.20906. [doi]
5. Q. Qin et al., “Velocity‐selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation,” Magn Reson Med, vol. 88, no. 4, pp. 1528–1547, Oct. 2022, doi: 10.1002/mrm.29371. [doi]
6. St. Lawrence KS, Frank JA, McLaughlin AC. Effect of restricted water exchange on cerebral blood flow values calculated with arterial spin tagging: a theoretical investigation. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine. 2000 Sep;44(3):440-9.doi: 10.1002/1522-2594(200009)44:3<440::AID-MRM15>3.0.CO;2-6 [doi]

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http://echo.ismrm.org/p/ISMRM2026/604-02-003