Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-03-010 ISMRM Abstract

Short echo 1H CSI of Downfield Metabolites in the Human Brain at 7T and 3T

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Neuro
469-03-010 · Software and Analysis for MR Spectroscopy and Chemical Shift Imaging · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row J
Keywords: Brain metabolism 1H MRS Ultra-High Field (UHF) Downfield MR spectroscopic imaging Chemical Shift Imaging (CSI)
Accepted
Slimane Tounekti1,2, Sophia Swago 1,2, Mark A Elliott1,2, RAVI PRAKASH REDDY NANGA1,2, neil wilson1,2, Ravinder Reddy1,2, Walter R Witschey1,2
1University of Pennsylvania, Philadelphia, United States of America
2Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Sophia Swago

Synopsis

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References

1. Swago S, Wilson NE, Elliott MA, et al. Quantification of Tryptophan and NAD+ Proton Magnetization Exchange With Water Using Downfield 1H MRS in the Human Brain at 7 T. Magn Reson Med. 2025. PMID: 41088554 [pmid]
2. Xue C, Li G, Zheng Q, et al. Tryptophan metabolism in health and disease. Cell Metab. 2023 Aug 8;35(8):1304-26. PMID: 37352864 [pmid]
3. Lautrup S, Sinclair DA, Mattson MP, et al. NAD+ in brain aging and neurodegenerative disorders. Cell Metab. 2019 Oct 1;30(4):630-55. PMID: 31577933 [pmid]
4. Özdemir İ, Etyemez S, Barker PB. High‐field downfield MR spectroscopic imaging in the human brain. Magn Reson Med. 2024 Sep;92(3):890-9. PMID: 38469953 [pmid]
5. Bagga P, Hariharan H, Witschey WR, et al. 3D CSI downfield 1H MR spectroscopy using EBURP1 spectrally selective excitation pulse. ISMRM.(online). 2020.
6. Wilson NE, Elliott MA, Nanga RPR, et al. Optimization of 1H-MRS methods for large-volume acquisition of low-concentration downfield resonances at 3 T and 7 T. Magn Reson Med. 2025 Jan;93(1):18-30. PMID: 39250517 [pmid]
7. Polyák H, Galla Z, Nánási N, et al. The tryptophan-kynurenine metabolic system is suppressed in cuprizone-induced model of demyelination simulating progressive multiple sclerosis. Biomedicines. 2023 Mar 20;11(3):945. PMID: 36979924 [pmid]
8. Laugeray A, Launay JM, Callebert J, et al. Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression. Behav Brain Res. 2010 Jun 26;210(1):84-91. PMID: 20153778 [pmid]
9. Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, Guillemin GJ, Smythe G, Sachdev P. Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology. 2014 Apr;15(2):177-98. PMID: 24337988 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/469-03-010