Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-009 ISMRM Abstract

Extraction of the vascular component of 13C-pyruvate signal: correlation with ASL

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Analysis Methods - Classification and Prediction
465-01-009 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: 1-13C Pyruvate Hyperpolarized 13C MRI Model fitting
Accepted
Biranavan Uthayakumar 1,2, Dylan A Dingwell1,2, Nicole Cappelletto1,2, Albert P Chen3, Nathan Ma4, Chris Heyn5, Hany Soliman6, Charles H Cunningham1,2
1Department of Medical Biophysics, University of Toronto, Toronto, Canada
2Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
3GE Healthcare, Taichung, Taiwan
4Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Canada
5Department of Radiology, Sunnybrook Health Sciences Centre, Toronto, Canada
6Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada
Presenting Author: Biranavan Uthayakumar

Synopsis

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References

1. John Kurhanewicz et al. “Hyperpolarized 13C MRI: path to clinical translation in oncology”. In: Neoplasia 21.1 (2019), pp. 1–16. PMID: 30472500 [pmid]
2. Zhen J Wang et al. “Hyperpolarized 13C MRI: state of the art and future directions”. In: Radiology 291.2 (2019), pp. 273–284 PMID: 30835184 [pmid]
3. Casey Y Lee et al. “Lactate topography of the human brain using hyperpolarized 13C-MRI”. In: Neuroimage 204 (2020), p. 116202. PMID: 31557546 [pmid]
4. Jasmine Y Hu et al. “Investigating cerebral perfusion with high resolution hyperpolarized [1-13C] pyruvate MRI”. In: Magnetic resonance in medicine 90.6 (2023), pp. 2233–2241. PMID: 37665726 [pmid]
5. Benjamin J Geraghty et al. “Dual-echo EPI sequence for integrated distortion correction in 3D time-resolved hyperpolarized 13C MRI”. In: Magnetic Resonance in Medicine 79.2 (2018), pp. 643–653. PMID: 28394085 [pmid]
6. Biranavan Uthayakumar et al. “Age-associated change in pyruvate metabolism investigated with hyperpolarized 13C-MRI of the human brain”. In: Human Brain Mapping (2023). PMID: 37219519 [pmid]
7. Huankai Huo et al. “3D whole brain segmentation using spatially localized atlas network tiles”. In: NeuroImage 194 (2019), pp. 105–119. PMID: 30910724 [pmid]
8. Timur V Elzhov et al. “Package ‘minpack. lm’”. In: Title R Interface Levenberg-Marquardt Nonlinear Least-Sq. Algorithm Found MINPACK Plus Support Bounds (2016).
9. Karline Soetaert, Thomas Petzoldt, and R Woodrow Setzer. “Solving differential equations in R: package deSolve”. In: Journal of statistical software 33 (2010), pp. 1–25.
10. Tyler Blazey et al. “Spatial distribution of hyperpolarized [1-13C] pyruvate MRI and metabolic PET in the human brain”. In: Imaging Neuroscience 3 (2025) https://doi.org/10.1162/IMAG.a.903 [doi]

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http://echo.ismrm.org/p/ISMRM2026/465-01-009